Methods of using Raman spectral information in determining analyte concentrations
First Claim
1. A non-invasive method of determining the concentration of an analyte using Raman spectral information, the method comprising the acts of:
- pinching an area of skin tissue;
placing a reflective material near or around the pinched skin tissue, the reflective material forming at least one opening therethrough;
applying a high-intensity, narrow band of light to the skin tissue through the at least one opening, the high-intensity light entering the pinched skin tissue and generating a Raman signal;
reflecting the high-intensity light and Raman signal that pass through the pinched skin tissue back into the pinched skin tissue via the reflective material;
collecting the Raman signal; and
determining the analyte concentration using the collected Raman signal, wherein the Raman signal is collected at a wavelength range of from about 300 to about 5000 nm.
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Abstract
A non-invasive method of determining the concentration of an analyte uses Raman spectral information. A high-intensity, narrow band of light (10) is applied to one side (12a) of skin tissue (12). The high-intensity light (10) enters the skin tissue and generates a Raman signal (16). A reflective material (22) is placed in a location nearest the other side (12b) of skin tissue (12). The reflective material (22) is located generally opposite of the entry (A) of the applied high-intensity light (10). The high-intensity light (10) and the Raman signal (20) that pass through the skin tissue (12) are reflected back into the skin tissue (12) via the reflective material (22). The Raman signal (16,20) is collected and the analyte concentration is determined using the collected Raman signal (16,20).
46 Citations
13 Claims
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1. A non-invasive method of determining the concentration of an analyte using Raman spectral information, the method comprising the acts of:
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pinching an area of skin tissue; placing a reflective material near or around the pinched skin tissue, the reflective material forming at least one opening therethrough; applying a high-intensity, narrow band of light to the skin tissue through the at least one opening, the high-intensity light entering the pinched skin tissue and generating a Raman signal; reflecting the high-intensity light and Raman signal that pass through the pinched skin tissue back into the pinched skin tissue via the reflective material; collecting the Raman signal; and determining the analyte concentration using the collected Raman signal, wherein the Raman signal is collected at a wavelength range of from about 300 to about 5000 nm. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification