Apparatus and method for assessing vascular health

• US 8,452,388 B2
• Filed: 05/12/2009
• Issued: 05/28/2013
• Est. Priority Date: 02/27/2009
• Status: Active Grant

• Current Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Original Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Inventors: Feldkamp, Joseph R., Heller, Jeffrey Robert
• Primary Examiner(s): PACKARD, BENJAMIN J
• Application Number:
  US12/464,640
• Publication Number:
  US 20100222696A1
• Time in Patent Office: 1,477 Days
• Field of Search: 600/547
• US Class Current: 600/547
• CPC Class Codes: A61B 2560/0431 Portable apparatus, e.g. comprising a handle or case
• CPC Class Codes: A61B 2560/0462 Apparatus with built-in sensors
• CPC Class Codes: A61B 5/0522 Magnetic induction tomography
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/6824 Arm or wrist

Abstract

Apparatus and methods for utilizing conductivity measurements to assess vascular health or to diagnose vascular conditions are disclosed. An exemplary method includes performing a first conductivity measurement of an extremity at a first elevation; elevating the extremity to a second elevation; performing a second conductivity measurement at the second elevation; and comparing the first conductivity measurement and the second conductivity measurement to determine a conductivity displacement Δσ. Another exemplary method includes maintaining a conductivity sensor adjacent to an individual for a period of time; performing a series of conductivity measurements; using the series of conductivity measurements to determine the transient behavior of the conductivity over the period of time; and using the transient behavior of the conductivity to assess the vascular health of the individual. A conductivity sensor and platform unit for performing conductivity measurements are also disclosed.

Claims

1. A method of determining a vascular condition of an individual, comprising:

performing a first conductivity measurement of an extremity of the individual at a first elevation;

elevating the extremity of the individual to a second elevation;

performing a second conductivity measurement of the extremity at the second elevation;

comparing the first conductivity measurement and the second conductivity measurement to determine a conductivity displacement of the extremity responsive to the elevation change of the extremity.

2. The method of claim 1, wherein the first and second conductivity measurements are performed with a conductivity sensor comprising an induction coil.

3. The method of claim 2, wherein the conductivity sensor is configured to probe the extremity at a depth of up to about 15 mm below the skin of the individual.

4. The method of claim 3, wherein the induction coil comprises:

a first conductive element that spirals outward to an external perimeter; and

a second conductive element operably connected to the first conductive element, the second conductive element spiraling inward from the external perimeter staggered relative to the first conductive element.

5. The method of claim 1, wherein the first elevation is located substantially at or below the elevation of the heart of the individual and the second elevation is located above the heart of the individual.

6. The method of claim 1, wherein the extremity of the individual is an arm.

7. The method of claim 1, wherein the extremity of the individual is a leg.

8. The method of claim 1, wherein the method comprises:

performing a blood pressure measurement of the extremity; and

using the blood pressure measurement in conjunction with the conductivity displacement Δ

σ

to determine the vascular condition of the individual.

9. The method of claim 8, wherein the blood pressure measurement is the diastolic blood pressure of the individual.

10. The method of claim 8, wherein the blood pressure measurement is the systolic blood pressure of the individual.

11. The method of claim 1, wherein the method comprises using the conductivity displacement to determine if the individual has peripheral artery disease.

12. The method of claim 1, wherein the method comprises using the conductivity displacement to monitor patient warming.

13. The method of claim 1, wherein the method comprises using the conductivity displacement to monitor circulatory shock.

14. The method of claim 8, wherein the method comprises using the conductivity displacement to determine if the individual has venous or arterial blockage.

20. The method of claim 1, wherein the series of conductivity measurements is performed on an extremity that is elevated above the heart of the individual.

15. A method of assessing the health of a vascular system of an individual, the method comprising:

performing a first conductivity measurement of the individual;

subjecting the vascular system to a stimulus by subjecting the individual to vigorous exercise;

subsequent to subjecting the vascular system to a stimulus, performing a second conductivity measurement of the individual; and

comparing the first conductivity measurement and the second conductivity measurement to determine a conductivity displacement responsive to the stimulus.

16. The method of claim 15, wherein the first conductivity measurement is performed on an extremity of the individual at a first elevation and the second conductivity measurement is performed on the extremity at a second elevation.

17. The method of claim 16, wherein the first elevation is located substantially at or below the elevation of the heart of the individual and the second elevation may be located above the heart of the individual.

18. The method of claim 15, wherein the first and second conductivity measurements are performed with a conductivity sensor comprising an induction coil configured to probe the extremity at a depth of up to about 15 mm below the skin of the individual.

19. A method of assessing vascular health of an individual, comprising:

maintaining a conductivity sensor adjacent to the individual for a period of time;

performing a series of conductivity measurements of the individual, the series of conductivity measurements comprising a plurality of conductivity measurements taken over the period of time;

using the series of conductivity measurements to determine the transient behavior of the conductivity of the individual over the period of time; and

using the transient behavior of the conductivity to assess the vascular health of the individual;

wherein the conductivity measurements are performed with a conductivity sensor comprising an induction coil, the induction coil comprising a first conductive element that spirals outward to an external perimeter, and a second conductive element operably connected to the first conductive element, the second conductive element spiraling inward from the external perimeter staggered relative to the first conductive element.

21. The method of claim 19, wherein the method comprises performing each of the plurality of conductivity measurements in the series of conductivity measurements at regular predetermined time intervals for the period of time.

22. The method of claim 19, wherein the series of conductivity measurements are performed with a conductivity sensor comprising an induction coil configured to probe the specimen at a depth of up to about 15 mm below the skin of the individual.

23. The method of claim 19, wherein the method comprises monitoring the transient behavior of the conductivity of the extremity to determine if the individual has peripheral artery disease.

24. The method of claim 19, wherein the method comprises monitoring the transient behavior of the conductivity of the extremity to monitor patient warming.

25. The method of claim 19, wherein the method comprises monitoring the transient behavior of the conductivity of the extremity to monitor circulatory shock.