Implantable medical device crosstalk evaluation and mitigation

• US 8,452,394 B2
• Filed: 01/30/2009
• Issued: 05/28/2013
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Burnes, John E., Krause, Paul G., Donofrio, William T., Reinke, James D., Arne, Gerald P., Peichel, David J., Zhou, Xiaohong, Davis, Timothy
• Primary Examiner(s): Lavert, Nicole F
• Application Number:
  US12/362,768
• Publication Number:
  US 20100114196A1
• Time in Patent Office: 1,579 Days
• Field of Search: 607 4- 5, 607/62
• US Class Current: 607/5
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means
• CPC Class Codes: A61N 1/37258 Alerting the patient
• CPC Class Codes: A61N 1/3962 in combination with another heart therapy
• CPC Class Codes: A61N 1/39622 Pacing therapy
• CPC Class Codes: A61N 1/39624 Pain reduction therapy

Abstract

Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

Claims

1. A method for mitigating crosstalk from an implanted electrical stimulator, when delivering electrical stimulation from the stimulator to a nonmyocardial tissue site, the method comprising:

adjusting the delivery of the electrical stimulation to the nonmyocardial tissue site responsive to detecting a potential cardiac arrhythmia; and

determining whether the potential arrhythmia is still detected after adjusting the electrical stimulation to the tissue site; and

modifying a stimulation parameter of the electrical stimulator responsive to the potential arrhythmia no longer being detected after adjusting the electrical stimulation to the tissue site.

2. The method of claim 1, wherein adjusting the delivery of the electrical stimulation to the nonmyocardial tissue site comprises suspending the delivery of the electrical stimulation to the tissue site.

3. The method of claim 1, wherein adjusting the delivery of the electrical stimulation comprises adjusting the delivery of the electrical stimulation at a first time and modifying the stimulation parameter of the electrical stimulator comprises modifying a value of a first stimulation parameter, the method further comprising:

delivering electrical stimulation to the nonmyocardial tissue site, via the implanted electrical stimulator, according to the modified stimulation parameter;

adjusting the delivery of the electrical stimulation to the nonmyocardial tissue site at a second time in response to detecting another potential arrhythmia, the detecting of the other potential arrhythmia occurring while delivering electrical stimulation according to the modified value of the first stimulation parameter;

determining whether the other potential arrhythmia is still detected after adjusting the electrical stimulation to the tissue site at the second time; and

modifying a value of a second stimulation parameter of the electrical stimulator responsive to the other potential arrhythmia no longer being detected after adjusting the electrical stimulation to the tissue site at the second time.

4. The method of claim 1, wherein adjusting the delivery of the electrical stimulation comprises adjusting the delivery of the electrical stimulation at a first time and modifying the stimulation parameter of the electrical stimulator comprises modifying a value of a stimulation parameter, the method further comprising:

delivering electrical stimulation to the nonmyocardial tissue site, via the implanted electrical stimulator, according to the modified stimulation parameter;

adjusting the delivery of the electrical stimulation to the tissue site at a second time in response to detecting another potential arrhythmia, the detecting of the other potential arrhythmia being while delivering electrical stimulation according to the modified value of the stimulation parameter;

determining whether the other potential arrhythmia is detected after adjusting the electrical stimulation to the tissue site at the second time; and

further modifying the value of the stimulation parameter of the electrical stimulator responsive to the other potential arrhythmia no longer being detected after adjusting the electrical stimulation to the tissue site at the second time.

5. The method of claim 1, further comprising:

delivering electrical stimulation to the nonmyocardial tissue site, via the implanted electrical stimulator, according to the modified stimulation parameter;

adjusting the delivery of the electrical stimulation to the tissue site in response to detecting another potential arrhythmia, the detecting of the other potential arrhythmia occurring while delivering electrical stimulation according to the at least one modified stimulation parameter of the electrical stimulator; and

generating an interference indication upon detecting the other potential arrhythmia.

6. The method of claim 5, further comprising transmitting the interference indication to a user via an external device.

7. The method of claim 6, wherein the external device comprises a medical device programmer.

8. The method of claim 5, wherein the interference indication comprises at least one of a visible alert, an audible alert or somatosensory alert.

9. The method of claim 1, wherein detecting the potential arrhythmia comprises detecting the potential arrhythmia with a device that is separate from the electrical stimulator.

10. The method of claim 1, wherein detecting the potential arrhythmia comprises detecting the potential arrhythmia with the electrical stimulator.

11. The method of claim 1, wherein the stimulation parameter comprises at least one of a slew rate, a current amplitude, a voltage amplitude, a pulse width, a pulse rate, a continuous waveform frequency, a duty cycle, an electrode combination, a timing of the delivery of the electrical stimulation relative to a cardiac cycle of the heart of the patient, a waveform shape or a signal envelope of the electrical stimulation signal.

12. The method of claim 1, wherein:

delivering electrical stimulation to the nonmyocardial tissue site via the implantable electrical stimulator, comprises delivering electrical stimulation to the tissue site via a subset of electrodes electrically coupled to the implantable electrical stimulator; and

modifying the stimulation parameter of the electrical stimulator comprises modifying the subset of electrodes to define a guarded cathode arrangement.

13. The method of claim 1, wherein:

delivering electrical stimulation to the nonmyocardial tissue site within a patient, via the implantable electrical stimulator, comprises delivering electrical stimulation generated in accordance with a first therapy program; and

modifying the stimulation parameter of the electrical stimulator comprises controlling the implantable electrical stimulator to generate the electrical stimulation according to a second therapy program that is different than the first therapy program.

14. A non-transitory computer-readable medium comprising instructions that cause a programmable processor of an implantable electrical stimulator to execute a method for mitigating crosstalk therefrom, when delivering electrical stimulation to a nonmyocardial tissue site, the method comprising:

adjusting the delivery of the electrical stimulation to the nonmyocardial tissue site after detecting a potential cardiac arrhythmia;

determining whether the potential arrhythmia is still detected after adjusting the electrical stimulation to the tissue site; and

modifying a stimulation parameter of the electrical stimulator responsive to the potential arrhythmia is no longer being detected after adjusting the electrical stimulation to the tissue site.

15. The computer-readable medium of claim 14, wherein adjusting the delivery of the electrical stimulation to the nonmyocardial tissue site comprises suspending the delivery of the electrical stimulation to the tissue site.

16. The computer-readable medium of claim 14, wherein adjusting the delivery of the electrical stimulation comprises adjusting the delivery of the electrical stimulation at a first time, and modifying the stimulation parameter of the electrical stimulator comprises modifying a value of a first stimulation parameter, and the method further comprises:

delivering electrical stimulation to the nonmyocardial tissue site, according to the modified stimulation parameter;

adjusting the delivery of the electrical stimulation to the nonmyocardial tissue site at a second time in response to detecting another potential arrhythmia, the detecting of the other potential arrhythmia being while delivering electrical stimulation according to the modified value of the first stimulation parameter;

determining whether the other potential arrhythmia is still detected after adjusting the electrical stimulation to the tissue site at the second time; and

modifying a value of a second stimulation parameter of the electrical stimulator responsive to the other potential arrhythmia no longer being detected after adjusting the electrical stimulation to the tissue site at the second time.

17. The computer-readable medium of claim 14, wherein adjusting the delivery of the electrical stimulation comprises adjusting the delivery of the electrical stimulation at a first time, and modifying the stimulation parameter of the electrical stimulator comprises modifying a value of a stimulation parameter, and the method further comprises:

delivering electrical stimulation to the nonmyocardial tissue site, according to the modified stimulation parameter;

adjusting the delivery of the electrical stimulation to the tissue site at a second time in response to detecting another potential arrhythmia, the detecting of the other potential arrhythmia being while delivering electrical stimulation according to the modified value of the stimulation parameter;

determining whether the other potential arrhythmia is detected after adjusting the electrical stimulation to the tissue site at the second time; and

further modifying the value of the stimulation parameter of the electrical stimulator responsive to the other potential arrhythmia no longer being detected after adjusting the electrical stimulation to the tissue site at the second time.

18. The computer-readable medium of claim 14, wherein the method further comprises:

delivering electrical stimulation to the nonmyocardial tissue site, according to the modified stimulation parameter;

adjusting the delivery of the electrical stimulation to the tissue site in response to detecting another potential arrhythmia, the detecting of the other potential arrhythmia occurring while delivering electrical stimulation according to the at least one modified stimulation parameter of the electrical stimulator; and

generating an interference indication upon detecting the other potential arrhythmia.

19. The computer-readable medium of claim 18, wherein the method further comprises transmitting the interference indication to a user via an external device.

20. The computer-readable medium of claim 18, wherein the external device comprises a medical device programmer.

21. The computer-readable medium of claim 18, wherein the interference indication comprises at least one of a visible alert, an audible alert or somatosensory alert.

22. The computer-readable medium of claim 14, wherein the stimulation parameter comprises at least one of a slew rate, a current amplitude, a voltage amplitude, a pulse width, a pulse rate, a continuous waveform frequency, a duty cycle, an electrode combination, a timing of the delivery of the electrical stimulation relative to a cardiac cycle of the heart of the patient, a waveform shape or a signal envelope of the electrical stimulation signal.

23. The computer-readable medium of claim 14, wherein modifying the stimulation parameter comprises modifying a subset of electrodes to define a guarded cathode arrangement, the electrodes being electrically coupled to the implantable stimulator for delivering the electrical stimulation to the nonmyocardial tissue site.