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Method and apparatus for synchronizing neural stimulation to cardiac cycles

  • US 8,452,398 B2
  • Filed: 05/20/2009
  • Issued: 05/28/2013
  • Est. Priority Date: 04/05/2005
  • Status: Expired due to Fees
First Claim
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1. A method for operating a neural stimulation system coupled to a living subject having a circulatory system, the method comprising:

  • delivering neural stimulation pulses from an implantable medical device;

    sensing a reference signal indicative of cardiac cycles each including a predetermined type timing reference event using an implantable reference signal sensor placed external to the circulatory system, wherein sensing the reference signal includes sensing a subcutaneous ECG signal using implantable electrodes incorporated onto the implantable medical device;

    detecting the predetermined type timing reference event from the reference signal;

    measuring an atrioventricular interval using the subcutaneous ECG signal; and

    controlling the delivery of the neural stimulation pulses using the detected predetermined type timing reference event and the measured atrioventricular interval, including synchronizing the delivery of the neural stimulation pulses to the detected predetermined type timing reference event.

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