Methods and compositions for the inhibition of biofilms on medical devices

• US 8,454,566 B2
• Filed: 07/10/2003
• Issued: 06/04/2013
• Est. Priority Date: 07/10/2003
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Van Antwerp, William P.
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): OSINSKI, BRADLEY JAMES
• Application Number:
  US10/616,784
• Publication Number:
  US 20050008671A1
• Time in Patent Office: 3,617 Days
• Field of Search: 604/103.02, 604/265, 604/286, 604/587, 604/288.01, 604/288.04, 604/287, 623/1.38, 623/1.46
• US Class Current: 604/265
• CPC Class Codes: A61K 31/496 Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Embodiments of the invention provide compositions which are effective to inhibit the development of biofilms on a surface of a medical device having the composition applied thereto, to medical devices having the composition applied to a surface thereof and to methods for using the compositions to coat medical devices.

Claims

1. A medical device having a surface coated with a composition comprising a lectin, wherein:

(a) the medical device includes a metallic material;

(b) the lectin binds a compound produced by a microorganism capable of forming a biofilm on the surface of the medical device so as to enhance attachment of the microorganism to the composition comprising the lectin; and

(c) the lectin is disposed within a biodegradable polymer composition that can slough away from the surface of the medical device when the lectin is bound to the compound produced by a microorganism,

so as to inhibit formation of a biofilm on the surface of the medical device.

2. The medical device of claim 1, wherein the biodegradable polymer is a biocompatible polymer that degrades at a controllable rate within an in vivo environment.

3. The medical device of claim 1, wherein the composition further comprises at least one agent that inhibits the growth of the microorganism.

4. The medical device of claim 3, wherein the agent is an antibiotic or an antifungal agent.

5. The medical device of claim 1, wherein the lectin binds to a compound produced by a microorganism selected from the group consisting of Pseudomonas aeruginosa, Streptococcus pneumoniae, Streptococcus viridans, Haemophilus influenzae, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis and Candida albicans.

6. The medical device of claim 1, wherein the lectin is wheat germ agglutinin or concanavalin A.

7. The medical device of claim 1, wherein the device is implantable.

8. The medical device of claim 7, wherein the device comprises a drug delivery pump, a pacemaker, a cochlear implant, a shunt, a catheter or a cannula.

9. The medical device of claim 1, wherein the metallic material is titanium or stainless steel.

10. The medical device of claim 1, wherein the medical device further includes a biostable polymeric material.

14. The medical device of claim 1 or claim 11, wherein the composition comprising the lectin is disposed on a region of the device having a mechanical structure that is compatible with the adherence of microorganisms.

11. A medical device having a surface coated with a composition comprising a lectin, wherein:

(a) the surface of the medical device includes a biostable polymeric material;

(b) the lectin binds a compound produced by a microorganism capable of forming a biofilm on the surface of the medical device so as to enhance attachment of the microorganism to the composition comprising the lectin; and

(c) the lectin is disposed within a biodegradable polymer composition that can slough away from the biostable polymeric material when the lectin is bound to the compound produced by a microorganism,

so as to inhibit formation of a biofilm on the surface of the medical device.

12. The medical device of claim 11, wherein the biostable polymeric material comprises polytetrafluoroethylene.

13. The medical device of claim 11, wherein the medical device further includes a metallic material.