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Enhanced pyruvate to 2,3-butanediol conversion in lactic acid bacteria

  • US 8,455,224 B2
  • Filed: 09/29/2009
  • Issued: 06/04/2013
  • Est. Priority Date: 09/29/2008
  • Status: Active Grant
First Claim
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1. A recombinant lactic acid bacterial cell comprising at least one gene encoding a heterologous polypeptide having butanediol dehydrogenase activity and at least one genetic modification that reduces pyruvate formate lyase activity, wherein the bacterial cell is substantially free of lactate dehydrogenase activity, and wherein the cell comprises a 2-butanol or 2-butanone biosynthetic pathway.

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