Compositions and methods for treating joints
First Claim
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1. A method for treating a joint condition, comprising:
- combining a solution of hyaluronic acid (HA) with a bone morphogenetic protein (BMP) to form a mixture in which the BMP is precipitated and dispersed at a concentration in the range of about 5 μ
g/ml to 90 μ
g/ml in the solution of HA, the mixture having a pH in the range of about 3 to 8; and
injecting the mixture into a subject to treat the joint condition, the BMP being capable of becoming solubilized and biologically active within the subject after injection.
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Abstract
Methods and compositions are disclosed for an intra-articular injection for the treatment of osteoarthritis. The methods and compositions comprising combinations of hyaluronic acid and a bone morphogenetic protein, like rhGDF-5, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.
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7 Claims
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1. A method for treating a joint condition, comprising:
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combining a solution of hyaluronic acid (HA) with a bone morphogenetic protein (BMP) to form a mixture in which the BMP is precipitated and dispersed at a concentration in the range of about 5 μ
g/ml to 90 μ
g/ml in the solution of HA, the mixture having a pH in the range of about 3 to 8; andinjecting the mixture into a subject to treat the joint condition, the BMP being capable of becoming solubilized and biologically active within the subject after injection. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification