System for heart performance characterization and abnormality detection

• US 8,457,724 B2
• Filed: 10/30/2009
• Issued: 06/04/2013
• Est. Priority Date: 12/11/2008
• Status: Active Grant

• Current Assignee: PixArt Imaging Incorporated
• Original Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Inventors: Zhang, Hongxuan
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): MAHMOOD, NADIA AHMAD
• Application Number:
  US12/610,267
• Publication Number:
  US 20100152598A1
• Time in Patent Office: 1,313 Days
• Field of Search: 600/515, 600/516, 600/517, 600/518, 607 4- 26
• US Class Current: 600/509
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle

Abstract

A system for heart performance characterization and abnormality detection, includes an acquisition device for acquiring an electrophysiological signal representing a heart beat cycle of a patient heart. A detector detects multiple parameters of the electrophysiological signal comprising at least one of, (a) amplitude, (b) time duration, (c) frequency and (d) time-frequency, representative parameters. A signal analyzer calculates at least one ratio of the detected parameters from ratios including, (i) ratio of T wave amplitude to P wave amplitude, (ii) ratio of time duration of ST wave to time duration of PR wave, (iii) ratio of a frequency of a PR wave to a frequency of a RT wave and (iv) ratio of a time-frequency measure of a PR wave to a time-frequency measure of a RT wave. A comparator determines whether a calculated ratio exceeds a predetermined upper limit threshold or a predetermined lower limit threshold. An output processor generates data representing an alert message in response to the calculated ratio exceeding a predetermined threshold.

Claims

1. A system configured for heart performance characterization and abnormality detection, comprising:

an acquisition device configured for acquiring an electrophysiological signal representing a heart beat cycle of a patient heart;

a detector configured for detecting a plurality of parameters of said electrophysiological signal comprising at least one of, (a) amplitude, (b) time duration, (c) frequency and (d) time-frequency, representative parameters;

a signal analyzer configured for calculating at least one ratio of the detected parameters from ratios including,

(i) ratio of T wave amplitude to P wave amplitude,

(ii) ratio of time duration of ST wave to time duration of PR wave,

(iii) ratio of a frequency of a PR wave to a frequency of a RT wave and

(iv) ratio of a time-frequency measure of a PR wave to a time-frequency measure of a RT wave;

a comparator configured for determining whether the at least one calculated ratio exceeds a predetermined upper limit threshold or a predetermined lower limit threshold; and

an output processor configured for generating data representing an alert message in response to said calculated ratio exceeding a predetermined threshold.

2. A system according to claim 1, wherein

said signal analyzer selects said frequency of said PR wave and said frequency of said RT wave to comprise at least one of, (a) an average frequency and (b) a dominant frequency.

3. A system according to claim 1, wherein

said signal analyzer selects said time-frequency measure of said PR wave and said time-frequency measure of said RT wave to comprise electrical voltage potentials determined by said detector using a bandpass filter.

4. A system according to claim 1, wherein said signal analyzer selects,

said ratio of T wave amplitude to P wave amplitude to comprise

5. A system according to claim 1, wherein

said signal analyzer additionally calculates a ratio of the detected parameters comprising

6. A system according to claim 1, wherein

said signal analyzer additionally calculates a ratio of the detected parameters comprising

7. A system according to claim 1, wherein

said signal analyzer additionally calculates a ratio of the detected parameters comprising at least one of,

8. A system according to claim 1, wherein

said signal analyzer additionally calculates a ratio of the detected parameters comprising

9. A system according to claim 1, wherein

said signal analyzer additionally calculates a ratio of the detected parameters comprising at least one of,

10. A system according to claim 1, wherein

said output processor generates data representing an alert message in response to a predetermined combination of calculated ratios exceeding a predetermined threshold.

11. A system according to claim 1, wherein

said system comprises a patient monitoring device.

12. A system according to claim 1, wherein

said output processor generates data representing said alert message indicating severity of a cardiac condition.

13. A system according to claim 1, wherein

said output processor generates data representing said alert message providing advance warning of myocardial ischemia or acute myocardial infarction in cases including non-symptomatic cases.

14. A system according to claim 1, including at least one of, (a) a device for initiating drug delivery and (b) a device for initiating electrical stimulus or pacing of a heart wherein

said output processor generates data representing said alert message for initiating treatment by at least one of, (a) initiating drug delivery and (b) initiating electrical stimulus or pacing of a heart.

15. A system according to claim 1, wherein

said output processor generates data representing said alert message supporting substantially real time diagnosis or treatment of a patient.

16. A system configured for heart performance characterization and abnormality detection, comprising:

an acquisition device configured for acquiring an electrophysiological signal representing a heart beat cycle of a patient heart;

a detector configured for detecting a plurality of parameters of said electrophysiological signal comprising at least one of, (a) amplitude, (b) time duration, (c) frequency and (d) time-frequency, representative parameters;

a signal analyzer configured for calculating at least one ratio of the detected parameters from ratios including,

(i) ratio of T wave amplitude to P wave amplitude,

(ii) ratio of time duration of ST wave to time duration of PR wave,

(iii) ratio of a frequency of a PR wave to a frequency of a RT wave and

(iv) ratio of a time-frequency measure of a PR wave to a time-frequency measure of a RT wave;

a comparator configured for determining whether the at least one calculated ratio exceeds a predetermined upper limit threshold or a predetermined lower limit threshold; and

a signal generator configured for generating a signal for adjusting operation of a heart assist device.

17. A system according to claim 16, wherein

said heart assist device comprises at least one of, (a) a heart pacing device, (b) a defibrillator and (c) a cardioverter.

18. A method for heart performance characterization and abnormality detection, comprising the activities of:

acquiring an electrophysiological signal representing a heart beat cycle of a patient heart;

detecting a plurality of parameters of said electrophysiological signal comprising at least one of, (a) amplitude, (b) time duration, (c) frequency and (d) time-frequency, representative parameters;

calculating at least one ratio of the detected parameters from ratios including,

(i) ratio of T wave amplitude to P wave amplitude,

(ii) ratio of time duration of ST wave to time duration of PR wave,

(iii) ratio of a frequency of a PR wave to a frequency of a RT wave and

(iv) ratio of a time-frequency measure of a PR wave to a time-frequency measure of a RT wave;

determining whether a calculated ratio exceeds a predetermined upper limit threshold or a predetermined lower limit threshold; and

generating data representing an alert message in response to said calculated ratio exceeding a predetermined threshold.