Method of fabricating an implantable medical device
First Claim
1. A method of fabricating an implantable medical device, comprising the steps of:
- a. providing a suitable sacrificial substrate;
b. vacuum depositing at least one of a metallic and pseudometallic biocompatible material onto the sacrificial substrate thereby forming a film of the biocompatible material;
c. imparting a plurality of microperforations passing through the film of biocompatible material thereby forming the implantable medical device; and
,d. separating the sacrificial substrate from the formed implantable medical device.
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Accused Products
Abstract
Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.
157 Citations
19 Claims
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1. A method of fabricating an implantable medical device, comprising the steps of:
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a. providing a suitable sacrificial substrate; b. vacuum depositing at least one of a metallic and pseudometallic biocompatible material onto the sacrificial substrate thereby forming a film of the biocompatible material; c. imparting a plurality of microperforations passing through the film of biocompatible material thereby forming the implantable medical device; and
,d. separating the sacrificial substrate from the formed implantable medical device. - View Dependent Claims (2, 3, 4)
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5. A method of fabricating an implantable medical device, comprising the steps of:
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a. providing a pre-existing blank of at least one of a biocompatible metallic and pseudometallic material; and
,b. removing sections of the pre-existing blank material to form a plurality of microperforations passing through the pre-existing blank material. - View Dependent Claims (6, 7, 8)
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9. A method of fabricating a microporous metallic implantable device, comprising the steps of:
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a. providing a cylindrical substrate in a hollow cathode magnetron sputtering deposition device; b. providing a cylindrical target of a nickel-titanium alloy; c. thermally insulating the cylindrical target from a cooling jacket; d. evacuating the deposition chamber to vacuum conditions; e. depositing a metal at a substrate temperature, a target temperature, a gas pressure, and with a negative bias voltage to the substrate to form a deposited film; f. forming a plurality of microperforations in the deposited film by removing regions of the deposited film; and g. removing the deposited film to form the microporous metallic implantable device. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification