Method and apparatus for monitoring brain activity

• US 8,460,196 B2
• Filed: 05/29/2009
• Issued: 06/11/2013
• Est. Priority Date: 05/29/2009
• Status: Expired due to Fees

• Current Assignee: Atlantis Limited Partnership
• Original Assignee: Atlantis Limited Partnership
• Inventors: Brainard, Edward C. II
• Primary Examiner(s): Natnithithadha, Navin
• Assistant Examiner(s): BERHANU, ETSUB D
• Application Number:
  US12/475,156
• Publication Number:
  US 20100305456A1
• Time in Patent Office: 1,474 Days
• Field of Search: 600/340, 600/483, 600/544
• US Class Current: 600/483
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/6816 Ear lobe

Abstract

Method for monitoring brain activity. Left and right cardiac pulse signals are detected at bilateral locations on a body for a selected number of cardiac cycles. Computing apparatus computes the standard deviation of the left and right pulse signals for the selected number of cardiac cycles. The standard deviations are normalized on the computing apparatus by dividing the left and right standard deviations by the mean of the left and right pulse signals computed over the selected number of cardiac cycles to produce a left and a right Coefficient of Variation of the pulse signals. A Bilateral Pulse Index is generated from the left and right Coefficients of Variation. The Bilateral Pulse Index relates to brain activity. Cardiac pulse signals from a single location on the body may be utilized in some embodiments.

Claims

1. Method for monitoring brain activity comprising:

detecting with a sensor or sensors left and right cardiac pulse signals at bilateral locations on a body for a selected number of cardiac cycles;

computing on a computing apparatus the standard deviation of the left and right pulse signals for the selected number of cardiac cycles;

normalizing on the computing apparatus the standard deviation of the left and right pulse signals by dividing the left and right standard deviations by the mean of the left and right pulse signals, respectively, computed over the selected number of cardiac cycles to produce a left and a right Coefficient of Variation (CV) of the pulse signals; and

generating a Bilateral Pulse Index (BPI) from the left and right Coefficients of Variation according to the equation BPI=((Left CV+Right CV)/2)+(Absolute (Left CV−

Right CV)),

wherein BPI relates to brain activity.

2. The method of claim 1 wherein the bilateral locations are left and right earlobes.

3. The method of claim 1 wherein the bilateral locations are left and right portions of a forehead.

5. The method of claim 1 wherein the brain activity is the sleep state.

6. The method of claim 1 wherein the brain activity is awareness under anesthesia.

7. The method of claim 1 wherein the pulse signals are detected by flesh penetrating electromagnetic radiation sensors.

8. The method of claim 1 wherein the pulse signals are detected by plethysmographic or oximeter sensors.

9. The method of claim 1 wherein the sensor or sensors are selected from the group consisting of optical sensors, RF displacement sensors, capacitance displacement sensors, pressure sensors, acoustic distance sensors, acoustic doppler flow sensors, optical displacement sensors, and ear canal sensors.

10. The method of claim 1 wherein the sensor or sensors are connected to the computing apparatus by cables that limit the introduction of motion artifacts during movement.

11. The method of claim 1 wherein the sensor or sensors form a two-channel instrument.

4. The method of 1 wherein the bilateral locations are left and right carotid arteries at the neck.