Progenitor endothelial cell capturing with a drug eluting implantable medical device
First Claim
1. An implantable medical device having comprising a luminal surface and a coating;
- wherein the coating comprises one or more layers of a biocompatible non-polymer matrix;
one or more pharmaceutical substances for extended or controlled release to adjacent tissue, and a ligand covalently attached to said matrix and operably configured to capture circulating endothelial progenitor cells on the luminal surface of said device after implantation of said medical device into a patient;
wherein the non-polymer matrix is formed of a porous material comprising nanoparticles, wherein the nanoparticles comprise a metal, or a metallic alloy, and wherein the ligand comprises an antibody, an antibody fragment or combinations thereof.
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Accused Products
Abstract
A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.
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Citations
30 Claims
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1. An implantable medical device having comprising a luminal surface and a coating;
- wherein the coating comprises one or more layers of a biocompatible non-polymer matrix;
one or more pharmaceutical substances for extended or controlled release to adjacent tissue, and a ligand covalently attached to said matrix and operably configured to capture circulating endothelial progenitor cells on the luminal surface of said device after implantation of said medical device into a patient;
wherein the non-polymer matrix is formed of a porous material comprising nanoparticles, wherein the nanoparticles comprise a metal, or a metallic alloy, and wherein the ligand comprises an antibody, an antibody fragment or combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- wherein the coating comprises one or more layers of a biocompatible non-polymer matrix;
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11. A method for treating vascular disease, comprising implanting into a patient in need of treatment a medical device having a luminal surface and a biocompatible coating;
- wherein the coating comprises a non-polymer matrix;
one or more pharmaceutical substances and a ligand covalently attached to said matrix and operably configured to capture circulating progenitor cells on the luminal surface of said medical device after implantation into said patient;
wherein the non-polymer matrix is formed of a porous material comprising nanoparticles, selected from a size of about 5 nm to about 5 micron in diameter and wherein the nanoparticles comprise a metal, or a metallic alloy. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
- wherein the coating comprises a non-polymer matrix;
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24. An implantable medical device comprising a lumen and a luminal surface, said luminal surface comprising a biocompatible coating comprising one or more layers of a non-polymer matrix, formed of a porous material comprising nanoparticles;
- wherein the nanoparticles comprise a metal, or a metallic alloy and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof covalently attached to said one or more layers of said non-polymer matrix, and being compatible to binding selectively a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood; and
capturing the endothelial progenitor cells on the luminal surface of the device in vivo;
wherein said coating releases said pharmaceutically acceptable intimal growth inhibitory substances on the external surface of said medical device and stimulates adherence and growth of said endothelial progenitor cells on the luminal surface of said medical device to rapidly form a confluent endothelium in situ. - View Dependent Claims (25, 26, 27, 28, 29, 30)
- wherein the nanoparticles comprise a metal, or a metallic alloy and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof covalently attached to said one or more layers of said non-polymer matrix, and being compatible to binding selectively a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood; and
Specification