Fenestrated wound repair scaffold

• US 8,460,691 B2
• Filed: 04/23/2010
• Issued: 06/11/2013
• Est. Priority Date: 04/23/2010
• Status: Active Grant

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: Lauritzen, Nels, Shimp, Lawrence A., Mitchell, Brent
• Primary Examiner(s): Long, Scott
• Assistant Examiner(s): Alawadi, Sarah
• Application Number:
  US12/766,494
• Publication Number:
  US 20110262515A1
• Time in Patent Office: 1,145 Days
• Field of Search: None
• US Class Current: 424/422
• CPC Class Codes: A61K 38/39 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/60 Materials for use in artificial skin
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

Fenestrated wound repair scaffolds and methods for forming scaffolds involve dispersing human collagen having a preserved amount of native constituents in solution, depositing the human collagen dispersion in a tray, forming openings in the collagen dispersion and removing the liquid component to form a fenestrated wound repair scaffold. Fenestrated wound repair scaffolds include a network of openings passing linearly through the wound repair scaffold to form channels for cells to pass into so as to form a series of cell formations therein.

Claims

1. A fenestrated wound repair scaffold comprising human collagen or human collagen products, said fenestrated wound repair scaffold comprising:

a first plurality of transverse channels each extending parallel to one another across a width of the scaffold oriented in a first direction and defining at least one opening in the scaffold to provide for movement of biological materials therethrough and into the scaffold, and

a second plurality of transverse channels each extending parallel to one another across a length of the scaffold oriented in a second direction generally perpendicular to the first plurality of transverse channels and defining at least one opening in the scaffold to provide for movement of biological materials therethrough and into the scaffold and the fenestrated wound repair scaffold comprises a series of embossed surface channels arranged along a length and a width of a top surface and a bottom surface of the fenestrated wound repair scaffold forming a matrix of intersecting embossed surface channels, wherein an axial channel extends between an embossed top surface channel intersection point and an embossed bottom surface channel intersection point.

2. The fenestrated wound repair scaffold of claim 1, wherein at least a portion of the first and second plurality of transverse channels are generally fluidly connected.

3. The fenestrated wound repair scaffold of claim 1, wherein the second plurality of transverse channels comprises a first set of channels and a second set of channels arranged generally transverse to the first set of channels.

4. The fenestrated wound repair scaffold of claim 3, wherein the first set of channels and the second set of channels are generally fluidly connected.

5. The fenestrated wound repair scaffold of claim 1, wherein a portion of the surface channels arranged along the length and the width intersect and form a matrix of geometric shapes, and a channel extends through a thickness of the fenestrated wound repair scaffold.

6. The fenestrated wound repair scaffold of claim 5, wherein the thickness is about 2 mm to about 3 mm.

7. The fenestrated wound repair scaffold of claim 1, wherein a ratio of the openings arranged in the scaffold is between about 10% and about 30%.

8. The fenestrated wound repair scaffold of claim 1, wherein said openings promote wound closure strength.

20. The fenestrated wound repair scaffold of claim 1, wherein the human collagen or the human collagen products comprise ground collagen, milled collagen, fibrillar collagen, or combinations thereof.

21. The fenestrated wound repaid scaffold of claim 1, wherein the first and second plurality of transverse channels are disposed between the embossed top surface channels and the embossed bottom surface channels such that the axial channel and the first and second plurality of transverse channels intersect.

9. A fenestrated wound repair scaffold comprising enzymatically-treated human-derived collagen having a preserved amount of its natural collagen constituents, wherein the fenestrated wound repair scaffold comprises:

a first plurality of transverse channels each extending parallel to one another across a width of the scaffold oriented in a first direction and defining at least one opening in the scaffold, and

a second plurality of transverse channels each extending parallel to one another across a length of the scaffold oriented in a second direction generally perpendicular to the first plurality of transverse channels and defining at least one opening in the scaffold;

wherein the openings of the first and second plurality of transverse channels define a network of openings passing generally linearly through the wound repair scaffold promoting the formation of a series of cell formations within the fenestrated wound repair scaffold and the fenestrated wound repair scaffold comprises a series of embossed surface channels arranged along a length and a width of a top surface and a bottom surface of the fenestrated wound repair scaffold forming a matrix of intersecting embossed surface channels, wherein an axial channel extends between an embossed top surface channel intersection point and an embossed bottom surface channel intersection point.

10. The fenestrated wound repair scaffold of claim 9, whereby the network of openings further promote wound closure strength.

11. The fenestrated wound repair scaffold of claim 9, wherein said scaffold comprises a graft for treating dermal wounds.

12. The fenestrated wound repair scaffold of claim 9, wherein said scaffold comprises a graft for treating pressure sores.

13. The fenestrated wound repair scaffold of claim 9, wherein said scaffold comprises a graft for treating venous stasis wounds.

14. The fenestrated wound repair scaffold of claim 9, wherein said scaffold comprises a graft for treating diabetic ulcers.

15. The fenestrated wound repair scaffold of claim 9, wherein said scaffold comprises a graft for reconstructive applications.

16. A wound repair scaffold comprising:

enzymatically-treated human derived collagen having a macroporous architecture with a nanofibrous collagen micro structure favorable for cell growth and supporting the growth of blood vessels into the scaffold,

a first plurality of transverse channels each extending parallel to one another across a width of the scaffold oriented in a first direction and defining at least one opening in the scaffold, and

a second plurality of transverse channels each extending parallel to one another across a length of the scaffold oriented in a second direction generally perpendicular to the first plurality of transverse channels and defining at least one opening in the scaffold and the fenestrated wound repair scaffold comprises a series of embossed surface channels arranged along a length and a width of a top surface and a bottom surface of the fenestrated wound repair scaffold forming a matrix of intersecting embossed surface channels, wherein an axial channel extends between an embossed top surface channel intersection point and an embossed bottom surface channel intersection point.

17. The wound repair scaffold of claim 16, wherein the nanofibrous micro structure comprises a plurality of aligned collagen nanofibers.

18. The wound repair scaffold of claim 16, wherein the openings and the first and second plurality of transverse channels define a matrix of reticulated pores configured to allow movement of cells and fluid in and along the length of the strand.

19. The wound repair scaffold of claim 18, wherein a plurality of reticulated pores are lined with collagen nanofibers.