Methods of treating psychosis and schizophrenia based on polymorphisms in the CNTF gene
First Claim
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1. A method of treating a psychotic disorder in a human individual in need of such treatment comprising:
- a) determining, in a biological sample, for each of the two copies of the CNTF gene present in the individual the identity of the nucleotide pair at the polymorphic site 103G>
A in GenBank sequence reference No. X55890 (Version
1),b) detecting the presence of GG at position 103 of the human individual andc) treating the individual with GG at position 103 with iloperidone.
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Abstract
This invention relates to the use of the association between the 103 G>A polymorphism in the CNTF gene to determine antipsychotic treatment strategies in patients with psychotic disorders.
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Citations
5 Claims
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1. A method of treating a psychotic disorder in a human individual in need of such treatment comprising:
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a) determining, in a biological sample, for each of the two copies of the CNTF gene present in the individual the identity of the nucleotide pair at the polymorphic site 103G>
A in GenBank sequence reference No. X55890 (Version
1),b) detecting the presence of GG at position 103 of the human individual and c) treating the individual with GG at position 103 with iloperidone. - View Dependent Claims (2, 3)
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4. A method of treating a psychotic disorder in a human individual in need of such treatment comprising:
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a) determining, in a biological sample, the level of mRNA of the CNTF gene wherein the CNTF gene is GenBank sequence reference No. X55890 (Version
1),b) comparing the level mRNA determined in the biological sample, to a value of mRNA levels corresponding to a GG at position 103 of the CNTF gene c) determining the human individual is GG at position 103 and d) treating the individual with GG at position 103 with iloperidone. - View Dependent Claims (5)
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Specification