Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins
First Claim
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1. An isolated variable domain of a camelid heavy-chain antibody (VHH domain) directed against a glial fibrillary acidic protein (GFAP), wherein said VHH domain comprises an amino acid sequence selected from the group consisting of the consensus amino acid sequence SEQ ID NO:
- 1, SEQ ID NO;
3, SEQ ID NO;
6, SEQ ID NO;
9 and SEQ ID NO;
12.
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Abstract
The present invention relates to the use of variable domains of camelid heavy-chain antibodies (VHH domains) directed against an intracellular target and having an isoelectric point of at least 8.5, for targeting said intracellular target or for the preparation of a peptide vector. Particularly, it concerns VHH domains directed against a glial fibrillary acidic protein and uses thereof for preparing therapeutic or diagnostic agents.
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Citations
22 Claims
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1. An isolated variable domain of a camelid heavy-chain antibody (VHH domain) directed against a glial fibrillary acidic protein (GFAP), wherein said VHH domain comprises an amino acid sequence selected from the group consisting of the consensus amino acid sequence SEQ ID NO:
- 1, SEQ ID NO;
3, SEQ ID NO;
6, SEQ ID NO;
9 and SEQ ID NO;
12. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
- 1, SEQ ID NO;
Specification