Immunosensor system for blood with reduced interference
First Claim
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1. An immunosensor system for blood with reduced interference, comprising:
- an immunosensor for blood samples that generates a signal based on the formation of a sandwich on a sensing surface between a first immobilized antibody to a target analyte, the target analyte, and a labeled antibody,wherein the sensing surface of said immunosensor further contains a second immobilized antibody covering at least a portion thereof that forms an immunocomplex between an endogenous or exogenous protein that is in the sample and that is not the target analyte, wherein the endogenous or exogenous protein is not labeled and does not contribute to the signal, and wherein the first immobilized antibody and the second immobilized antibody are present on the same region of the immunosensor.
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Abstract
An electrochemical immunosensor system with reduced interference, comprising: a first immunosensor that generates an electrochemical signal based on the formation of a sandwich between an immobilized antibody, a target analyte and a labeled antibody, wherein a portion of the signal arises from non-specific binding of the labeled antibody in the region of the first immunosensor, and
- a second immunosensor that acts as an immuno-reference sensor and generates a signal that is the same as or predictably related to the degree of non-specific binding which occurs in the region of the first immunosensor, and has an immunocomplex between an immobilized antibody and an endogenous or exogenous protein that is in the sample and that is not the target analyte.
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15 Claims
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1. An immunosensor system for blood with reduced interference, comprising:
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an immunosensor for blood samples that generates a signal based on the formation of a sandwich on a sensing surface between a first immobilized antibody to a target analyte, the target analyte, and a labeled antibody, wherein the sensing surface of said immunosensor further contains a second immobilized antibody covering at least a portion thereof that forms an immunocomplex between an endogenous or exogenous protein that is in the sample and that is not the target analyte, wherein the endogenous or exogenous protein is not labeled and does not contribute to the signal, and wherein the first immobilized antibody and the second immobilized antibody are present on the same region of the immunosensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. An immunosensor system for blood with reduced interference, comprising:
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an immunosensor for blood samples that generates a signal based on the formation of a sandwich on a sensing surface between a first immobilized antibody to a target analyte, the target analyte, and a labeled antibody, wherein the sensing surface of said immunosensor further contains a second immobilized antibody covering at least a portion thereof that forms an immunocomplex between human serum albumin (HSA) that is in the sample and that is not the target analyte, and wherein the first immobilized antibody and the second immobilized antibody are present on the same region of the immunosensor.
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Specification