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B7-H1 antibodies and method of use

  • US 8,460,927 B2
  • Filed: 10/25/2011
  • Issued: 06/11/2013
  • Est. Priority Date: 11/30/1999
  • Status: Expired due to Fees
First Claim
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1. A method for inhibiting a co-stimulatory effect of B7-H1 on T-cells, comprising:

  • contacting said B7-H1 with an isolated antibody that binds specifically to a B7-H1 polypeptide which comprises(a) amino acids having the sequence set forth in SEQ ID NO;

    1;

    or(b) amino acids that are encoded by a polynucleotide comprising nucleotides having the sequence set forth in SEQ ID NO;

    2,wherein the contacting comprises culturing the antibody with the T-cell in vitro, to thereby inhibit a co-stimulatory effect of B7-H1 on T-cells.

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