LOX and LOXL2 inhibitors and uses thereof
First Claim
Patent Images
1. An isolated antibody or antigen binding fragment thereof, comprising a heavy chain variable region comprising the amino acid sequence set forth as SEQ ID NO:
- 25, 26, 27, or 28, and a light chain variable region comprising the amino acid sequence set forth as SEQ ID NO;
30, 31, or 32, wherein the isolated antibody or antigen binding fragment thereof specifically binds a lysyl oxidase-like 2 (LOXL2) protein.
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Abstract
The present application relates to anti-LOX and anti-LOXL2 antibodies and their use in purification, diagnostic and therapeutic methods. Antibodies include monoclonal antibodies, humanized antibodies and functional fragments thereof. Anti-LOX and anti-LOXL2 antibodies can be used to identify and treat conditions such as a fibrotic condition, angiogenesis, or to prevent a transition from an epithelial cell state to a mesenchymal cell state.
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Citations
30 Claims
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1. An isolated antibody or antigen binding fragment thereof, comprising a heavy chain variable region comprising the amino acid sequence set forth as SEQ ID NO:
- 25, 26, 27, or 28, and a light chain variable region comprising the amino acid sequence set forth as SEQ ID NO;
30, 31, or 32, wherein the isolated antibody or antigen binding fragment thereof specifically binds a lysyl oxidase-like 2 (LOXL2) protein. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 20, 21, 23)
- 25, 26, 27, or 28, and a light chain variable region comprising the amino acid sequence set forth as SEQ ID NO;
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2. An isolated antibody or antigen binding fragment thereof, comprising a heavy chain variable region comprising the amino acid sequence set forth as SEQ ID NO:
- 25, 26, 27, or 28, wherein the isolated antibody or antigen binding fragment thereof specifically binds a lysyl oxidase-like 2(LOXL2) protein.
- View Dependent Claims (13, 14, 15, 16, 24, 25, 26)
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3. An isolated antibody or antigen binding fragment thereof, comprising a light chain variable region comprising the amino acid sequence set forth as SEQ ID NO:
- 30, 31, or 32, wherein the isolated antibody or antigen binding fragment thereof specifically binds a lysyl oxidase-like 2 (LOXL2) protein.
- View Dependent Claims (17, 18, 19, 27, 28, 29)
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4. An isolated antibody or antigen binding fragment thereof, comprising the complementarity determining regions (CDRs), CDR1, CDR2, and CDR3, of a heavy chain variable region comprising the amino acid sequence set forth as SEQ ID NO:
- 25, 26, 27, or 28, and the CDRs, CDR1, CDR2, and CDR3, of a light chain variable region comprising the amino acid sequence set forth as SEQ ID NO;
30, 31, or 32, wherein the isolated antibody or antigen binding fragment thereof specifically binds a lysyl oxidase-like 2(LOXL2) protein. - View Dependent Claims (22, 30)
- 25, 26, 27, or 28, and the CDRs, CDR1, CDR2, and CDR3, of a light chain variable region comprising the amino acid sequence set forth as SEQ ID NO;
Specification