Polymorphs of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[C][1,2]oxaborol-1-OL
First Claim
Patent Images
1. A crystalline polymorph of a hydrochloride salt of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol characterized by having essentially all of the °
- 2θ
values listed in Table 1±
0.2°
2θ
;
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Abstract
This invention provides, among other things, polymorphs of the hydrochloride salt of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.
54 Citations
14 Claims
-
1. A crystalline polymorph of a hydrochloride salt of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol characterized by having essentially all of the °
- 2θ
values listed in Table 1±
0.2°
2θ
;
- View Dependent Claims (5, 6, 7, 8, 9, 10)
- 2θ
-
2. A crystalline polymorph of a hydrochloride salt of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol having, upon X-ray crystallographic analysis, crystal parameters of substantially the following values:
-
Crystallographic system;
orthorhombicSpace group;
P212121Crystal dimensions;
a=9.1045(2) Å
, b=10.3107(2) Å
, c=14.5988(3) Åα
=90.00°
, β
=90.00°
, γ
=90.00°Volume 1370.44(5) Å
3Z, calculated density 4, 1.326 g cm−
3.
-
-
3. A crystalline polymorph of a hydrochloride salt of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol, characterized by having upon Raman spectroscopic analysis, all of the peaks having substantially the wavenumbers (cm−
- 1) of 3076.4, 3054.6, 2987.4, 2975.5, 2954.2, 2928.0, 2909.8, 2896.0, 1578.6, 1298.2, 1291.6, 1263.0, 1226.8, 1068.9, and 694.9, ±
50 wave numbers. - View Dependent Claims (4)
- 1) of 3076.4, 3054.6, 2987.4, 2975.5, 2954.2, 2928.0, 2909.8, 2896.0, 1578.6, 1298.2, 1291.6, 1263.0, 1226.8, 1068.9, and 694.9, ±
-
11. A crystalline polymorph of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.HCl having, upon X-ray crystallographic analysis, essentially all of the following °
- 2θ
values, ±
0.2°
2θ
;
7.8, 12.3, 14.0, 20.2, 21.3, 22.4, 23.3, 24.7, 27.6, and 32.1.
- 2θ
-
12. A crystalline polymorph of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.HCl having, upon X-ray crystallographic analysis, essentially all of the following °
- 2θ
values, ±
0.2°
2θ
;
6.2, 8.8, 9.8, 12.4, 13.9, 17.7, 22.3, 23.1, 24.3, 24.8, 26.1, 27.2, 28.0, 30.9, 32.2, and 33.
- 2θ
-
13. A crystalline polymorph of a hydrochloride salt of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol, produced by evaporation and/or recrystallization from a solution of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.HCl wherein the concentration of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.HCl is from about 11 mg/mL to about 30 mg/mL.
-
14. A crystalline polymorph of a hydrochloride salt of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol, produced by evaporation and/or recrystallization from a solution of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.HCl wherein the concentration of (S)-3-aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol.HCl is from about 15 mg/mL to about 50 mg/mL.
Specification