Microelectrode with laterally extending platform for reduction of tissue encapsulation

• US 8,463,353 B2
• Filed: 05/23/2012
• Issued: 06/11/2013
• Est. Priority Date: 01/26/2006
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Seymour, John P., Kipke, Daryl R.
• Primary Examiner(s): Cohen, Lee S
• Application Number:
  US13/478,746
• Publication Number:
  US 20120323103A1
• Time in Patent Office: 384 Days
• Field of Search: 600/377, 600/378, 607/116
• US Class Current: 600/377
• CPC Class Codes: A61B 2562/125 characterised by the manufacture of electrodes
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/685 Microneedles
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0558 Anchoring or fixation means therefor

Abstract

In some embodiments, an implantable microelectrode is provided with a shank comprised of a laterally extending platform whose thickness and/or configuration contributes to reduced tissue encapsulation, with at least one electrode site disposed at least partially on or in the laterally extending platform. Novel methods of designing, making, and using an implantable microelectrode or biosensor resulting in reduced tissue encapsulation are also disclosed.

Claims

1. An implantable microelectrode comprising:

a shank comprising;

a backbone portion; and

a laterally extending platform having a thickness less than the backbone portion and

extending radially from the backbone portion;

an electrode site disposed at least partially on or in the laterally extending platform; and

a conductive interconnect, disposed between insulating layers of dielectric in at least one of the shank and the laterally extending platform, that terminates with the electrode site.

2. The implantable microelectrode of claim 1, wherein at least a portion of the laterally extending platform has a thickness of approximately 10 microns or less.

3. The implantable microelectrode of claim 1, wherein the laterally extending platform comprises at least one longitudinal rib displaced laterally from the backbone portion and at least one radially projecting rib projecting from the backbone portion, wherein the configuration of the backbone portion, longitudinal rib, and radially projecting rib defines at least one open space in the laterally extending platform.

4. The implantable microelectrode of claim 3, wherein the electrode site is disposed at least partially on or in the longitudinal rib.

5. The implantable microelectrode of claim 1, wherein the electrode site is at least partially disposed on a top or bottom side of a portion of the laterally extending platform.

6. The implantable microelectrode of claim 5, wherein the electrode site is disposed within approximately 10 microns of a most lateral edge of the laterally extending platform disposed farthest from the backbone portion.

7. The implantable microelectrode of claim 6, wherein the electrode site has a lateral edge substantially flush with the most lateral edge of the laterally extending platform.

8. The implantable microelectrode of claim 1, wherein the electrode site is wrapped around an edge of the laterally extending platform.

9. The implantable microelectrode of claim 1, comprising a plurality of electrode sites disposed on the laterally extending platform and a plurality of conductive interconnects disposed between insulating layers of dielectric in at least one of the shank and the laterally extending platform, wherein each of the conductive interconnects terminates with a respective electrode site.

10. The implantable microelectrode of claim 9, wherein the electrode sites comprise a recording electrode site or a stimulation electrode site.

11. The implantable microelectrode of claim 1, further comprising a head having a distal end coupled to the shank.

12. The implantable microelectrode of claim 11, wherein the distal end of the head is coupled to the laterally extending platform.

13. An implantable microelectrode comprising:

a shank comprising;

a backbone portion; and

a laterally extending platform having a thickness less than the backbone portion and

extending radially from the backbone portion, wherein the thickness of the laterally extending platform is approximately 10 microns or less;

a plurality of electrode sites disposed at least partially on or in the laterally extending platform;

a plurality of conductive interconnects disposed between insulating layers of dielectric in at least one of the shank and the laterally extending platform, wherein each conductive interconnect terminates with a respective electrode site; and

a plurality of bond pads, at least some of which are in contact with a respective interconnect.

14. The implantable microelectrode of claim 13, wherein the laterally extending platform comprises at least one longitudinal rib displaced laterally from the backbone portion and at least one radially projecting rib projecting from the backbone portion, wherein the configuration of the backbone portion, longitudinal rib, and radially projecting rib defines at least one open space in the laterally extending platform.

15. The implantable microelectrode of claim 14, wherein the electrode site is disposed at least partially on or in the longitudinal rib.

16. The implantable microelectrode of claim 13, wherein the electrode site is at least partially disposed on a top or bottom side of a portion of the laterally extending platform.

17. The implantable microelectrode of claim 16, wherein the electrode site is disposed within approximately 10 microns of a most lateral edge of the laterally extending platform disposed farthest from the backbone portion.

18. The implantable microelectrode of claim 17, wherein the electrode site has a lateral edge substantially flush with the most lateral edge of the laterally extending platform.

19. The implantable microelectrode of claim 17, wherein the laterally extending platform extends approximately 250 microns or less radially from the backbone portion.

20. The implantable microelectrode of claim 13, wherein the electrode site is wrapped around an edge of the laterally extending platform.