Temperature assisted stimulation

• US 8,463,377 B2
• Filed: 05/06/2010
• Issued: 06/11/2013
• Est. Priority Date: 05/26/2009
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Maskara, Barun, Hamann, Jason J., Ruble, Stephen, Stolen, Craig
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): PIATESKI, ERIN M
• Application Number:
  US12/775,215
• Publication Number:
  US 20100305632A1
• Time in Patent Office: 1,132 Days
• Field of Search: 607/3
• US Class Current: 607/3
• CPC Class Codes: A61N 1/3629 in combination with non-electric therapy

Abstract

Various embodiments of an implantable system for delivering therapy comprise at least one of a heat sink or source to either reduce or increase temperature of excitable tissue, a pulse generator and at least one stimulation electrode to deliver electrical stimulation to excitable tissue, a memory and a controller. The memory has instructions for performing at least one stimulation routine and at least one thermal routine, and further has integration instructions for integrating the thermal routine(s) with the stimulation routine(s). The controller is configured to operate on the instructions to perform the stimulation routine(s) using the pulse generator and the at least one stimulation electrode, to perform the thermal routine(s) using the heat sink or the heat source, and to operate on the integration instructions to integrate thermal routine(s) with the stimulation routine(s).

Claims

1. An implantable system for delivering therapy, comprising:

at least one of a heat sink configured to reduce temperature of excitable tissue or a heat source configured to increase temperature of excitable tissue;

a pulse generator and at least one stimulation electrode configured to deliver electrical stimulation to excitable tissue;

a memory with instructions for performing at least one stimulation routine to electrically stimulate the excitable tissue and for performing at least one thermal routine to change the temperature of the excitable tissue, and further with integration instructions for performing an integration routine to integrate the at least one thermal routine with the at least one stimulation routine; and

a controller configured to operate on the instructions to perform the at least one stimulation routine to electrically stimulate the excitable tissue using the pulse generator and the at least one stimulation electrode, to perform the at least one thermal routine to change temperature of the excitable tissue using the heat sink or the heat source, and to operate on the integration instructions to perform the integration routine to integrate the at least one thermal routine with the at least one stimulation routine,

wherein in performing the integration routine the controller is configured to coordinate timing between changing temperature of the excitable tissue and electrically stimulating the excitable tissue,

wherein the system is implantable in a patient having a chronic condition indicated for a chronic therapy and further having an acute condition indicated for an acute therapy, and the controller is configured to;

apply electrical stimulation for the chronic therapy and change temperature for the acute therapy;

or

apply electrical stimulation for the acute therapy and change temperature for the chronic therapy;

or

apply electrical stimulation for the chronic therapy and change temperature for the acute therapy, and apply electrical stimulation for the acute therapy and change temperature for the chronic therapy.

2. The system of claim 1, wherein the pulse generator and the at least one stimulation electrode are configured to deliver electrical stimulation to nerve tissue.

3. The system of claim 2, wherein the integration instructions to be operated on by the controller include instructions for adjusting temperature to modulate nerve activity in the electrically stimulated nerve tissue.

4. The system of claim 2, wherein the integration instructions to be operated on by the controller include instructions for adjusting temperature to selectively encourage or inhibit nerve activity in the electrically stimulated nerve tissue.

5. The system of claim 1, wherein the pulse generator and the at least one stimulation electrode are configured to deliver electrical stimulation to cardiac tissue.

6. The system of claim 1, wherein the integration instructions to be operated on by the controller include instructions for adjusting temperature to adjust a stimulation threshold for electrically stimulating and capturing the excitable tissue.

7. The system of claim 1, wherein the system is configured to implement a method for stimulating cardiac tissue, comprising:

changing a stimulation threshold of excitable tissue from a first level to a second level in preparation for stimulating the nerve tissue, wherein changing the stimulation threshold of the excitable tissue includes changing a temperature of the excitable tissue; and

stimulating the nerve tissue at a stimulation site when the stimulation threshold is at the second level.

8. The system of claim 7, wherein changing the stimulation threshold of excitable tissue includes changing the stimulation threshold of the cardiac tissue.

9. The system of claim 8, wherein changing the stimulation threshold of the cardiac tissue includes reducing the stimulation threshold of the cardiac tissue from the first level to the second level.

10. The system of claim 9, wherein reducing the stimulation threshold of the cardiac tissue includes increasing the temperature of the cardiac tissue.

11. The system of claim 7, wherein changing the stimulation threshold of excitable tissue includes changing the stimulation threshold of nerve tissue.

12. The system of claim 11, wherein changing the stimulation threshold of nerve tissue includes increasing the stimulation threshold of the nerve tissue from the first level to the second level.

13. The system of claim 12, wherein increasing the stimulation threshold of the nerve tissue includes decreasing the temperature of the nerve tissue.

14. The system of claim 11, wherein changing the stimulation threshold of nerve tissue includes increasing the stimulation threshold of a phrenic nerve.

15. The system of claim 1, wherein the system is configured to implement a method for stimulating nerve tissue, comprising:

the controller is configured to operate on the integration instructions to change the temperature of the excitable tissue to change the response of the excitable tissue to the electrical stimulation.

16. The system of claim 15, wherein changing the stimulation threshold of excitable tissue includes changing the stimulation threshold of the nerve tissue at the stimulation site.

17. The system of claim 16, wherein changing the stimulation threshold of the nerve tissue at the stimulation site includes decreasing the stimulation threshold of the nerve tissue at the stimulation site, wherein decreasing the stimulation threshold includes increasing temperature of the nerve tissue at the stimulation site.

18. The system of claim 15, wherein changing the stimulation threshold of excitable tissue includes changing the stimulation threshold of other nerve tissue at another site than the stimulation site.

19. The system of claim 18, wherein changing the stimulation threshold of other nerve tissue includes increasing the stimulation threshold of the other nerve tissue, wherein increasing the stimulation threshold includes decreasing temperature of the nerve tissue at the stimulation site.

20. The system of claim 1, wherein:

the integration instructions in the memory include integration instructions for modifying a response of the excitable tissue to the electrical stimulation by changing temperature of the excitable tissue; and

changing a stimulation threshold of excitable tissue from a first level to a second level in preparation for stimulating the cardiac tissue, wherein changing the stimulation threshold of the excitable tissue includes changing a temperature of the excitable tissue; and

stimulating the cardiac tissue when the stimulation threshold is at the second level.

21. The system of claim 1, wherein:

the integration instructions in the memory include integration instructions to electrically stimulate a nerve to modulate nerve activity and to change temperature in the nerve to block or reduce nerve traffic in some fibers of the nerve; and

the controller is configured to operate on the integration instructions to electrically stimulate the nerve to modulate nerve activity and to change temperature in the nerve to block or reduce nerve traffic in some fibers of the nerve.

22. The system of claim 1, wherein:

the integration instructions in the memory include integration instructions to change temperature to modulate nerve activity in a nerve and to electrically stimulate the nerve to block or reduce nerve traffic in some fibers of the nerve; and

the controller is configured to operate on the integration to change temperature to modulate nerve activity in a nerve and to electrically stimulate the nerve to block or reduce nerve traffic in some fibers of the nerve.

23. The system of claim 1, further comprising a respiration detector configured to detect respiration and inspiration, wherein the integration instructions in the memory include integration instructions to change temperature to inhibit sympathetic nerve activity during inspiration, and to electrically stimulate parasympathetic nerve activity during inspiration.

24. The system of claim 1, further comprising a respiration detector configured to detect respiration and inspiration, wherein the integration instructions in the memory include integration instructions to electrically inhibit sympathetic nerve activity during inspiration and to thermally augment parasympathetic nerve activity during inspiration.