Encapsulated or coated stent systems
First Claim
Patent Images
1. A single strand stent system comprising;
- one or more single strand stent(s), each stent having at least one single strand twisted to form one or more open loops, the one or more open loops configured to be positioned around the lumen or passageway of a vessel, the at least one single strand including blunt distal and proximal ends, the at least one single strand further coated or encapsulated with a protein based material, the protein based material formed by a process including crosslinking a thermoplastic biocoacervate material that is administered to the one or more single strand stent(s);
the thermoplastic biocoacervate material formed by a process including;
adding one or more glycosaminoglycan(s) to a solution of one or more soluble or solubilized primary protein(s), wherein at least one of the one or more primary protein(s) is dissolved in one or more solvent(s) and includes collagen;
minimally mixing the one or more glycosaminoglycan(s) with the one or more primary protein(s) and one or more solvent(s) to precipitate an amorphous coacervate that falls out of the solution as a protein body;
extracting the protein body from the solution and forming the protein body into the thermoplastic biocoacervate material.
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Abstract
A stent system having zero or more inner stents inserted into an outer stent. The inner stents and outer stent are separated and/or encapsulated by a protein-based material of a protein matrix and/or a set biocoacervate, each one or more biocompatible proteins and one or more biocompatible solvents. The protein-based material may also include one or more carbohydrates and one or more pharmacologically active agents.
122 Citations
27 Claims
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1. A single strand stent system comprising;
one or more single strand stent(s), each stent having at least one single strand twisted to form one or more open loops, the one or more open loops configured to be positioned around the lumen or passageway of a vessel, the at least one single strand including blunt distal and proximal ends, the at least one single strand further coated or encapsulated with a protein based material, the protein based material formed by a process including crosslinking a thermoplastic biocoacervate material that is administered to the one or more single strand stent(s);
the thermoplastic biocoacervate material formed by a process including;adding one or more glycosaminoglycan(s) to a solution of one or more soluble or solubilized primary protein(s), wherein at least one of the one or more primary protein(s) is dissolved in one or more solvent(s) and includes collagen; minimally mixing the one or more glycosaminoglycan(s) with the one or more primary protein(s) and one or more solvent(s) to precipitate an amorphous coacervate that falls out of the solution as a protein body; extracting the protein body from the solution and forming the protein body into the thermoplastic biocoacervate material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A vessel graft fastener comprising;
one or more clamping devices adjoined by a linking member including a cloth or mesh material;
the one or more clamping devices and linking member coated or encapsulated with a protein-based material formed by administering a thermoplastic biocoacervate material to the one or more clamping devices and the liking member and crosslinking the thermoplastic biocoacervate material to set the thermoplastic biocoacervate material, the biocoacervate is formed by a process including;adding one or more glycosaminoglycan(s) to a solution of one or more soluble or solubilized primary protein(s) that are dissolved in one or more solvent(s), wherein at least one of the primary protein(s) includes collagen; minimally mixing the glycosaminoglycan(s) with the primary protein(s) and one or more solvent(s) to precipitate an amorphous coacervate that falls out of the solution as a protein body; extracting the protein body from the solution, and; forming the protein body into the thermoplastic biocoacervate. - View Dependent Claims (11, 12, 13, 14, 15, 16)
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17. A stent system comprising:
two or more metallic or polymeric stents that are capable of being integrated one stent within another stent; and
a biomaterial coating coated or encapsulated on one or more of the stents and formed by applying a thermoplastic amorphous biocoacervate to the one or more stents, the biocoacervate including one or more soluble or solubilized primary proteins, one or more secondary proteins, one or more glycosaminoglycans(s), and one or more biocompatible solvents, the biomaterial is formed by a process including;adding the one or more glycosaminoglycan(s) to a solution of one or more of the primary protein(s) that are dissolved in the one or more biocompatible solvents, wherein at least one of the primary protein(s) includes collagen; minimally mixing the glycosaminoglycan(s) with the one or more primary and secondary protein(s) and one or more solvent(s) to precipitate an amorphous coacervate that falls out of the solution as a protein body; forming the protein body into the thermoplastic amorphous biocoacervate, and; crosslinking the biocoacervate with one or more crosslinking agents to form the biomaterial. - View Dependent Claims (18, 19, 20, 21)
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22. A stent system comprising:
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two or more metallic or polymeric stents including an inner stent fitted within one or more outer stents; and
first and second protein based materials coating or encapsulating two or more of the two or more stents, the first and/or second protein based materials including a crosslinked biomaterial that is formed by a process including;adding one or more glycosaminoglycan(s) to a solution of one or more soluble or solubilized primary protein(s) that are dissolved in one or more solvent(s), wherein at least one of the one or more primary protein(s) includes collagen; minimally mixing the one or more glycosaminoglycan(s) with the one or more primary protein(s) and the one or more solvent(s) to precipitate an amorphous coacervate that falls out of the solution as a protein body; extracting and forming the protein body into a thermoplastic amorphous biocoacervate, and; crosslinking the thermoplastic amorphous biocoacervate, wherein the first protein based material is encapsulated or coated on the inner stent and is biocompatible with host material present in a host lumen, wherein the second protein based material is encapsulated or coated on one or more of the outer stents and is different from the first protein-based material, and wherein the second protein based material is configured to be biocompatible when in contact with host tissue positioned adjacent to the one or more outer stents. - View Dependent Claims (23, 24, 25, 26, 27)
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Specification