Illumination of integrated analytical systems
First Claim
1. A device for exciting a fluorophore, said device comprising:
- a first region having a reaction cell configured to receive a fluorophore;
a second region laterally adjacent the first region, the second region including a metal-insulator-metal (MIM) structure for providing plasmonic energy to the reaction cell;
a fourth region including an optical waveguide and inlet for receiving optical energy; and
a third region operationally positioned between the second region and the fourth region, the third region including a transition portion at one end of the waveguide adjacent the MIM structure, the transition portion dimensioned and configured to direct the received optical energy to the MIM structure.
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Accused Products
Abstract
An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.
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Citations
12 Claims
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1. A device for exciting a fluorophore, said device comprising:
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a first region having a reaction cell configured to receive a fluorophore; a second region laterally adjacent the first region, the second region including a metal-insulator-metal (MIM) structure for providing plasmonic energy to the reaction cell; a fourth region including an optical waveguide and inlet for receiving optical energy; and a third region operationally positioned between the second region and the fourth region, the third region including a transition portion at one end of the waveguide adjacent the MIM structure, the transition portion dimensioned and configured to direct the received optical energy to the MIM structure. - View Dependent Claims (2, 3, 4)
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5. A device for exciting a fluorophore, said device comprising:
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a metal layer for generating plasmons based on plasmon modes in response to optical energy, the metal layer comprising top and bottom portions; a dielectric slab extending between the top and bottom portions of the metal layer; a waveguide disposed between either the top or bottom portion of the metal layer and the dielectric slab, the waveguide configured to receive optical energy and transmit the optical energy to metal-dielectric interfaces to generate the plasmon modes; and a reaction cell disposed adjacent to the ends of the dielectric slab and metal layer, the reaction cell configured to receive a fluorophore; wherein the metal layer and slab are in communication with the reaction cell whereby plasmons generated in the metal are transmitted to the reaction cell. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12)
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Specification