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Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer

  • US 8,465,743 B2
  • Filed: 09/14/2010
  • Issued: 06/18/2013
  • Est. Priority Date: 10/01/2009
  • Status: Active Grant
First Claim
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1. A chimeric antigen receptor (CAR) comprising:

  • (a) an antigen binding domain of a KDR-1121 or DC101 antibody wherein the antigen binding domain comprises an amino acid sequence comprising SEQ ID NO;

    1 or 2;

    (b) an amino acid sequence comprising SEQ ID NO;

    3, 4, or 7; and

    (c) an amino acid sequence comprising SEQ ID NO;

    5, 6, 8, or 9.

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