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Granule and orally disintegrating tablet comprising oxycodone

  • US 8,465,776 B2
  • Filed: 07/31/2007
  • Issued: 06/18/2013
  • Est. Priority Date: 08/04/2006
  • Status: Active Grant
First Claim
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1. A granule consisting essentially of a neutral core coated by:

  • (a) oxycodone or a pharmaceutically acceptable salt of oxycodone, and (b) at least a binding agent, said oxycodone coating being further coated by a subcoat consisting of a compound soluble in gastric fluids and optionally an antistatic agent, wherein said subcoat is further coated by a taste-masking coating consisting of a polymer or copolymer with dialkylaminoalkyl(meth)acrylate units, which is insoluble at a pH above 5.5 but is soluble in gastric juice, and optionally an antistatic agent or a pore-forming agent, wherein the subcoat is adapted to avoid direct contact between the oxycodone or the pharmaceutically acceptable salt of oxycodone and the taste-masking coating such that degradation of oxycodone is inhibited.

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