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Variable region sequences of IL-31 monoclonal antibodies and methods of use

  • US 8,466,262 B2
  • Filed: 09/04/2007
  • Issued: 06/18/2013
  • Est. Priority Date: 09/01/2006
  • Status: Active Grant
First Claim
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1. An isolated monoclonal antibody or antigen-binding fragment thereof that is capable of specifically binding to a polypeptide consisting of amino acid residues 27-164 of SEQ ID NO:

  • 2, wherein the monoclonal antibody or antigen-binding fragment comprises a light chain variable region having the amino acid sequence of SEQ ID NO;

    8 and a heavy chain variable region having the amino acid sequence of SEQ ID NO;

    9; and

    wherein the monoclonal antibody or antigen-binding fragment further comprises a human IgG4 Fc molecule.

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