Image-guided thermotherapy based on selective tissue thermal treatment
First Claim
Patent Images
1. A device for thermotherapy, comprising:
- a catheter including a working channel configured for insertion into a passage of a body to reach a target tissue inside the body;
an optical imaging module comprising(1) an imaging optic fiber having a portion inserted into the working channel, wherein the imaging optic fiber is structured to support light in a first propagation mode and a second, different propagation mode,(2) an optical probe head coupled to an end of the imaging optic fiber and located inside the working channel,(3) a light source to produce probe light, wherein the imaging optic fiber receives and guides the probe light in the first propagation mode, wherein the optical probe head is coupled to the imaging optic fiber to receive the light from the imaging optic fiber and to reflect a first portion of the light back to the imaging optic fiber in the first propagation mode and direct a second portion of the light to a target location of the target tissue, the probe head collecting reflection of the second portion from the target location and exporting to the imaging optic fiber the reflection as a reflected second portion in the second propagation mode,(4) an optical differential delay unit to produce and control a relative delay between the reflected first portion and the reflected second portion received from the imaging optic fiber in response to a control signal,(5) a detection module to receive the reflected first portion and the reflected second portion from the imaging optic fiber and to extract information of the target tissue carried by the reflected second portion, and6) an imaging control unit, which produces the control signal to the optical differential delay unit, to set the relative delay at two different bias values to select a layer of material inside the target tissue to measure an optical absorption of the selected layer;
a thermotherapy module having a power delivery waveguide having a portion inserted into the working channel to deliver thermal energy to the target tissue;
a control unit that controls the optical imaging module to extract the imaging information from the collected reflected light, to obtain a spatial distribution of diseased locations of the target tissue, and to obtain a temperature map of the target tissue for thermotherapy based on the spatial distribution of the diseased locations of the target tissue, the control unit controlling the thermotherapy module to control a location and an amount of thermal energy delivery to each of the diseased locations based on the temperature map to perform thermotherapy.
3 Assignments
0 Petitions
Accused Products
Abstract
Devices and techniques for thermotherapy based on optical imaging.
-
Citations
28 Claims
-
1. A device for thermotherapy, comprising:
-
a catheter including a working channel configured for insertion into a passage of a body to reach a target tissue inside the body; an optical imaging module comprising (1) an imaging optic fiber having a portion inserted into the working channel, wherein the imaging optic fiber is structured to support light in a first propagation mode and a second, different propagation mode, (2) an optical probe head coupled to an end of the imaging optic fiber and located inside the working channel, (3) a light source to produce probe light, wherein the imaging optic fiber receives and guides the probe light in the first propagation mode, wherein the optical probe head is coupled to the imaging optic fiber to receive the light from the imaging optic fiber and to reflect a first portion of the light back to the imaging optic fiber in the first propagation mode and direct a second portion of the light to a target location of the target tissue, the probe head collecting reflection of the second portion from the target location and exporting to the imaging optic fiber the reflection as a reflected second portion in the second propagation mode, (4) an optical differential delay unit to produce and control a relative delay between the reflected first portion and the reflected second portion received from the imaging optic fiber in response to a control signal, (5) a detection module to receive the reflected first portion and the reflected second portion from the imaging optic fiber and to extract information of the target tissue carried by the reflected second portion, and 6) an imaging control unit, which produces the control signal to the optical differential delay unit, to set the relative delay at two different bias values to select a layer of material inside the target tissue to measure an optical absorption of the selected layer; a thermotherapy module having a power delivery waveguide having a portion inserted into the working channel to deliver thermal energy to the target tissue; a control unit that controls the optical imaging module to extract the imaging information from the collected reflected light, to obtain a spatial distribution of diseased locations of the target tissue, and to obtain a temperature map of the target tissue for thermotherapy based on the spatial distribution of the diseased locations of the target tissue, the control unit controlling the thermotherapy module to control a location and an amount of thermal energy delivery to each of the diseased locations based on the temperature map to perform thermotherapy. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
-
-
28. A method for thermotherapy, comprising:
-
directing an imaging optical beam to a target tissue, wherein the optical beam is directed to the target tissue in a first propagation mode; directing a first portion of the optical beam in the first propagation mode at a location near the target tissue away from the target tissue before the first portion reaches the target tissue while allowing a second portion in the first propagation mode to reach the target tissue; controlling a reflection of the second portion from the target tissue to be in second propagation mode different from the first propagation mode to produce a reflected second portion; directing both the first portion in the first propagation mode and the reflected second portion in the second propagation mode through a common waveguide into a detection module to obtain information from the reflected second portion on the target tissue; producing and controlling a relative delay between the first portion and the reflected second portion in response to a control signal to set the relative delay at two different bias values to select a layer of material inside the target tissue to measure an optical absorption of the selected layer; processing the obtained image information of the target tissue to obtain a spatial distribution of the diseased locations of the target tissue; generating a temperature map of the target tissue for thermotherapy based on the spatial distribution of the diseased locations of the target tissue; and controlling the thermal energy delivery to each of the diseased locations and cooling at the surface of each diseased locations based on the temperature map to perform the thermotherapy.
-
Specification