Calculating insulin on board for an extended bolus being delivered by an insulin delivery device

• US 8,467,980 B2
• Filed: 02/17/2012
• Issued: 06/18/2013
• Est. Priority Date: 07/18/2008
• Status: Active Grant

• Current Assignee: Insulet Corporation
• Original Assignee: Insulet Corporation
• Inventors: Campbell, Robert, Abramovich, Amanda
• Primary Examiner(s): BHAT, ADITYA S
• Application Number:
  US13/399,279
• Publication Number:
  US 20120150144A1
• Time in Patent Office: 487 Days
• Field of Search: 702/50
• US Class Current: 702/50
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

A system and method may be used to calculate insulin on board (IOB) for an extended bolus being delivered by an insulin infusion pump. In general, the system and method calculates an extended bolus IOB value for the extended bolus, which takes into account the insulin currently on board from the extended bolus and the insulin scheduled to be delivered by the extended bolus over a subsequent time period equivalent to a duration of insulin action. The extended bolus IOB value may be used to calculate a suggested bolus.

Claims

1. A computer implemented method of calculating insulin on board (IOB) for a user of an insulin infusion device, the method, performed via one or more processors, comprising:

determining if the insulin infusion device is currently delivering an extended bolus;

if the insulin infusion device is currently delivering at least one extended bolus, calculating at least one extended bolus insulin on board (IOB) value that takes into account an amount of insulin currently on board up to that point in time from the extended bolus and an amount of insulin scheduled to be delivered from the extended bolus within a subsequent time period substantially equal to a duration of insulin action;

determining if the insulin infusion device has delivered any previous bolus within a previous time period substantially equal to the duration of insulin action;

if the insulin infusion device has delivered at least one previous bolus within the previous time period, calculating at least one previous insulin on board (IOB) value for the at least one previous bolus; and

adding the at least one extended bolus IOB value and the at least one previous IOB value to produce a total IOB value.

2. The method of claim 1 wherein calculating the at least one previous IOB value includes calculating a meal IOB value representing insulin currently on board from a previous meal bolus given within the previous time period and a correction IOB value representing insulin currently on board from a previous correction bolus given within the previous time period.

3. The method of claim 1 wherein calculating the extended bolus IOB value comprises:

determining a completed IOB value representing an amount of insulin on board from a completed portion of the extended bolus that has been completed within a previous time period substantially equal to a duration of insulin action;

determining a scheduled IOB value representing an amount of insulin scheduled to be delivered during a scheduled portion of the extended bolus within a subsequent time period substantially equal to the duration of insulin action; and

adding the completed IOB value to the scheduled IOB value to produce the extended bolus IOB value.

4. A computer implemented method of determining a suggested bolus of insulin to be delivered by an insulin infusion device, the method, performed via one or more processors, comprising:

determining if the insulin infusion device is currently delivering an extended bolus;

if the insulin infusion device is currently delivering at least one extended bolus, calculating at least one extended bolus insulin on board (IOB) value that takes into account an amount of insulin currently on board up to that point in time from the extended bolus and an amount of insulin scheduled to be delivered from the extended bolus within a subsequent time period substantially equal to a duration of insulin action;

determining if the insulin infusion device has delivered any previous bolus within a previous time period substantially equal to the duration of insulin action;

if the insulin infusion device has delivered at least one previous bolus within the previous time period, calculating at least one previous insulin on board (IOB) value for the at least one previous bolus; and

calculating a suggested bolus using at least one calculated IOB value selected from the group consisting of the at least one extended bolus IOB value and the at least one previous IOB value.

5. The method of claim 4 wherein calculating the extended bolus IOB value comprises:

determining a completed IOB value representing an amount of insulin on board from a completed portion of the extended bolus that has been completed within a previous time period substantially equal to a duration of insulin action;

determining a scheduled IOB value representing an amount of insulin scheduled to be delivered during a scheduled portion of the extended bolus within a subsequent time period substantially equal to the duration of insulin action; and

adding the completed IOB value to the scheduled IOB value to produce the extended bolus IOB value.

6. The method of claim 4 wherein calculating a suggested bolus dose includes:

calculating a meal bolus portion representing an amount of insulin to cover a carbohydrate intake;

calculating a correction bolus portion representing an amount of insulin to correct blood glucose to within a target blood glucose range; and

adding the carbohydrate bolus and the correction bolus and subtracting the at least one calculated IOB value.

7. The method of claim 6 wherein the suggested bolus is an extended bolus.

8. The method of claim 4 wherein calculating the at least one previous IOB value includes calculating a meal IOB value representing insulin currently on board from a previous meal bolus given within the previous time period and a correction IOB value representing insulin currently on board from a previous correction bolus given within the previous time period.

9. The method of claim 8 wherein calculating a suggested bolus dose includes calculating a meal bolus representing an amount of insulin to cover a carbohydrate intake and subtracting the correction IOB value.

10. The method of claim 8 wherein calculating a suggested bolus dose includes calculating a correction bolus representing an amount of insulin to correct blood glucose to within a target blood glucose range and subtracting the at least one extended bolus IOB value, the meal IOB value, and the correction IOB value.

11. A non-transitory machine-readable medium whose contents cause a processor to perform a method of calculating insulin on board (IOB) for a user of an insulin infusion device, the method comprising:

determining if the insulin infusion device is currently delivering an extended bolus;

if the insulin infusion device is currently delivering at least one extended bolus, calculating at least one extended bolus insulin on board (IOB) value that takes into account an amount of insulin currently on board up to that point in time from the extended bolus and an amount of insulin scheduled to be delivered from the extended bolus within a subsequent time period substantially equal to a duration of insulin action;

determining if the insulin infusion device has delivered any previous bolus within a previous time period substantially equal to the duration of insulin action;

if the insulin infusion device has delivered at least one previous bolus within the previous time period, calculating at least one previous insulin on board (IOB) value for the at least one previous bolus; and

adding the at least one extended bolus IOB value and the at least one previous IOB value to produce a total IOB value.

12. The non-transitory machine-readable medium of claim 11 wherein calculating the at least one previous IOB value includes calculating a meal IOB value representing insulin currently on board from a previous meal bolus given within the previous time period and a correction IOB value representing insulin currently on board from a previous correction bolus given within the previous time period.

13. The non-transitory machine-readable medium of claim 11 wherein calculating the extended bolus IOB value comprises:

determining a completed IOB value representing an amount of insulin on board from a completed portion of the extended bolus that has been completed within a previous time period substantially equal to a duration of insulin action;

determining a scheduled IOB value representing an amount of insulin scheduled to be delivered during a scheduled portion of the extended bolus within a subsequent time period substantially equal to the duration of insulin action; and

adding the completed IOB value to the scheduled IOB value to produce the extended bolus IOB value.

14. A non-transitory machine-readable medium whose contents cause a processor to perform a method of determining a suggested bolus of insulin to be delivered by an insulin infusion device, the method comprising:

determining if the insulin infusion device is currently delivering an extended bolus;

if the insulin infusion device is currently delivering at least one extended bolus, calculating at least one extended bolus insulin on board (IOB) value that takes into account an amount of insulin currently on board up to that point in time from the extended bolus and an amount of insulin scheduled to be delivered from the extended bolus within a subsequent time period substantially equal to a duration of insulin action;

determining if the insulin infusion device has delivered any previous bolus within a previous time period substantially equal to the duration of insulin action;

if the insulin infusion device has delivered at least one previous bolus within the previous time period, calculating at least one previous insulin on board (IOB) value for the at least one previous bolus; and

calculating a suggested bolus using at least one calculated IOB value selected from the group consisting of the at least one extended bolus IOB value and the at least one previous IOB value.

15. The non-transitory machine-readable medium of claim 14 wherein calculating the extended bolus IOB value comprises:

determining a completed IOB value representing an amount of insulin on board from a completed portion of the extended bolus that has been completed within a previous time period substantially equal to a duration of insulin action;

determining a scheduled IOB value representing an amount of insulin scheduled to be delivered during a scheduled portion of the extended bolus within a subsequent time period substantially equal to the duration of insulin action; and

adding the completed IOB value to the scheduled IOB value to produce the extended bolus IOB value.

16. The non-transitory machine-readable medium of claim 14 wherein calculating a suggested bolus dose includes:

calculating a meal bolus portion representing an amount of insulin to cover a carbohydrate intake;

calculating a correction bolus portion representing an amount of insulin to correct blood glucose to within a target blood glucose range; and

adding the carbohydrate bolus and the correction bolus and subtracting the at least one calculated IOB value.

17. The non-transitory machine-readable medium of claim 16 wherein the suggested bolus is an extended bolus.

18. The non-transitory machine-readable medium of claim 14 wherein calculating the at least one previous IOB value includes calculating a meal IOB value representing insulin currently on board from a previous meal bolus given within the previous time period and a correction IOB value representing insulin currently on board from a previous correction bolus given within the previous time period.

19. The non-transitory machine-readable medium of claim 18 wherein calculating a suggested bolus dose includes calculating a meal bolus representing an amount of insulin to cover a carbohydrate intake and subtracting the correction IOB value.

20. The non-transitory machine-readable medium of claim 18 wherein calculating a suggested bolus dose includes calculating a correction bolus representing an amount of insulin to correct blood glucose to within a target blood glucose range and subtracting the at least one extended bolus IOB value, the meal IOB value, and the correction IOB value.