Wireless monitoring of laboratory animals
First Claim
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1. A system for detecting the position of a portion of a laboratory animal, comprising:
- a first coil and a second coil aligned along a longitudinal axis, wherein a laboratory animal is placed on a floor located at approximately the mid point between the first and second coil;
a resonant circuit attached to a portion of said laboratory animal, said resonant circuit defining a resonant frequency;
a signal generator electrically coupled to said coil and configured to drive said at least one coil with at least a first drive signal comprising a first frequency and a second drive signal comprising a second frequency, wherein the second frequency is more distant from said resonant frequency than the first frequency; and
a detection circuit coupled to said at least one coil and configured to detect an impedance change in said at least one coil between application of said first frequency to said at least one coil and application of said second frequency to said at least one coil, and to generate an output signal representative of resonant circuit position with respect to said at least one coil based at least in part on said impedance change.
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Abstract
Systems and methods for monitoring laboratory animals includes a tag comprising an inductive element and a capacitive element attached to a portion of a laboratory animal. The position of the portion is detected by monitoring the effect of the tag on a time-varying magnetic field having different frequencies, one near tag resonance, and one away from tag resonance.
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Citations
21 Claims
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1. A system for detecting the position of a portion of a laboratory animal, comprising:
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a first coil and a second coil aligned along a longitudinal axis, wherein a laboratory animal is placed on a floor located at approximately the mid point between the first and second coil; a resonant circuit attached to a portion of said laboratory animal, said resonant circuit defining a resonant frequency; a signal generator electrically coupled to said coil and configured to drive said at least one coil with at least a first drive signal comprising a first frequency and a second drive signal comprising a second frequency, wherein the second frequency is more distant from said resonant frequency than the first frequency; and a detection circuit coupled to said at least one coil and configured to detect an impedance change in said at least one coil between application of said first frequency to said at least one coil and application of said second frequency to said at least one coil, and to generate an output signal representative of resonant circuit position with respect to said at least one coil based at least in part on said impedance change. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of detecting the position of a portion of a laboratory animal, comprising:
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attaching a resonant circuit to said portion of said laboratory animal; placing said laboratory animal on a floor located at approximately a midpoint between a first coil and a second coil aligned along a longitudinal axis separated by a vertical distance; driving said at least one coil with a signal of at least a first frequency and a second frequency; and detecting an impedance change in said at least one coil between said first and second frequencies. - View Dependent Claims (15, 16, 17)
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18. A method of assaying for an anti-nociceptive drug, comprising:
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attaching a resonant circuit to a paw of a rodent; administering a potential anti-nociceptive drug to a rodent; exposing said paw to a nociceptive stimulus; placing said rodent on a floor located at approximately a midpoint between a first coil and a second coil aligned along a longitudinal axis, the first and second coils separated by a vertical distance; driving said at least one coil with a signal of at least a first frequency and a second frequency; and detecting paw guarding by detecting an impedance change in the first coil and the second coil between said first and second frequencies. - View Dependent Claims (19, 20, 21)
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Specification