Filtration system for preparation of fluids for medical applications

• US 8,469,331 B2
• Filed: 04/09/2007
• Issued: 06/25/2013
• Est. Priority Date: 04/07/2006
• Status: Active Grant

• Current Assignee: Nxstage Medical Incorporated (Fresenius Medical Care AG)
• Original Assignee: Nxstage Medical Incorporated (Fresenius Medical Care AG)
• Inventors: Burbank, Jeffrey H., Brugger, James M.
• Primary Examiner(s): Ganey, Steven J
• Application Number:
  US12/296,415
• Publication Number:
  US 20090182263A1
• Time in Patent Office: 2,269 Days
• Field of Search: 251/4, 251/7, 251/9, 251/10, 251/342, 604/250
• US Class Current: 251/4
• CPC Class Codes: A61J 1/05 for collecting, storing or administering blood, plasma or medical fluids multiple bags systems for separating or storing blood components A61M1/0209; Infusion or perfusion containers
• CPC Class Codes: A61J 1/1468 Containers characterised by specific material properties
• CPC Class Codes: A61J 1/1475 Inlet or outlet ports
• CPC Class Codes: A61J 1/2003 Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00 ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1668 Details of containers
• CPC Class Codes: A61M 1/167 Flexible packaging for solid concentrates
• CPC Class Codes: A61M 1/1672 using membrane filters, e.g. for sterilising the dialysate
• CPC Class Codes: A61M 1/1674 using UV radiation sources for sterilising the dialysate
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/3413 Diafiltration
• CPC Class Codes: A61M 1/342 Adding solutions to the blood, e.g. substitution solutions for preventing coagulation A61M1/3672
• CPC Class Codes: A61M 1/3462 Circuits for the preparation thereof
• CPC Class Codes: A61M 2205/273 preventing reuse, e.g. of disposables
• CPC Class Codes: A61M 39/1011 Locking means for securing connection; Additional tamper safeties A61M39/16 takes precedence
• CPC Class Codes: A61M 39/288 by bending or twisting the tube
• CPC Class Codes: B01D 61/14 Ultrafiltration; Microfiltration
• CPC Class Codes: B01D 61/145 Ultrafiltration
• CPC Class Codes: B01D 61/146 comprising multiple ultrafiltration steps
• CPC Class Codes: B01D 63/00 : Apparatus in general for separation processes using semi-permeable membranes
• CPC Class Codes: B01L 2200/026 : Fluid interfacing between devices or objects, e.g. connectors, inlet details
• CPC Class Codes: B01L 2200/0605 : Metering of fluids
• CPC Class Codes: B01L 2200/0689 : Sealing
• CPC Class Codes: B01L 2300/0681 : Filter
• CPC Class Codes: B01L 2300/0864 : comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
• CPC Class Codes: B01L 3/502 : with fluid transport, e.g. in multi-compartment structures centrifugal-type cuvettes G01N21/07; analysis by separation into components G01N30/00; automatic analysers G01N35/00
• CPC Class Codes: B65B 3/28 : by weighing
• CPC Class Codes: B65B 3/30 : by volumetric measurement
• CPC Class Codes: B65B 55/04 : Sterilising wrappers or receptacles prior to, or during, packaging sterilising bottles B67C7/00
• CPC Class Codes: C02F 1/444 : by ultrafiltration or microfiltration
• CPC Class Codes: C02F 2103/026 : Treating water for medical or cosmetic purposes
• CPC Class Codes: F16K 7/068 : by bending the hose
• CPC Class Codes: F16L 55/00 : Devices or appurtenances for use in, or in connection with, pipes or pipe systems the preceding groups and groups F16L57/00, F16L59/00 take precedence; repairing or joining pipes on or under water F16L1/26; nozzles B05B; cleaning of pipes B08B9/02; arrangements of draining devices for water main or service pipe systems E03B7/08; devices for preventing bursting of water pipes by freezing E03B7/10; draining devices for hydrants E03B9/14; for domestic plumbing installations E03C1/00; steam traps for draining of liquids from enclosures containing gases or vapours F16T; arrangements for sealing leaky tubes or conduits of heat-exchangers F28F11/00
• CPC Class Codes: F16L 55/07 : Arrangement or mounting of devices, e.g. valves, for venting or aerating or draining apparatus for draining F16T
• CPC Class Codes: Y10T 137/8593 : Systems

Abstract

Systems, methods, and devices for preparation of purified water and medicaments for various uses including blood treatment are described. Methods, devices, and systems for creating multiple-treatment batches are described.

Claims

1. A fluid line sealing device comprising:

a tube connected to a port of a batch fluid container, the tube being configured to transport fluid through an interior thereof;

a clamping member arranged on an exterior of the tube such that the clamping member can be moved along the tube, the clamping member being configured to hold a portion of the tube in a folded configuration so as to prevent fluid from flowing through said interior; and

a sliding collar arranged on an exterior of the tube such that the sliding collar can be moved along the tube and held in place on the tube by friction and having a substantially cylindrical shape, the sliding collar being configured to interact with said portion of the tube such that patency of said portion of the tube is restored in an unfolded configuration after said folded configuration,

wherein an inner diameter of the sliding collar is substantially the same as an outer diameter of the tube.

2. The fluid line sealing device of claim 1, wherein the clamping member has a clamping portion and a leash portion, the clamping portion holds the portion of the tube in the folded configuration, the tube is completely external to an interior of the clamping portion in the unfolded configuration, and the leash portion supports the clamping member on the tube in both the folded and unfolded configurations.

3. The fluid line sealing device of claim 1, wherein the clamping member includes a retaining portion for supporting the clamping member on the tube when the tube is in the unfolded configuration.

4. The fluid line sealing device of claim 1, wherein the sliding collar and the clamping member are configured such that the clamping member does not obstruct motion of the sliding collar when the tube is in the unfolded configuration.

5. The fluid line sealing device of claim 1, wherein the sliding collar is arranged on the exterior of the tube separately from the clamping member.

6. The fluid line sealing device of claim 1, wherein the sliding collar is elongate and has a constant cross section.

7. The fluid line sealing device of claim 1, wherein the sliding collar is closely conforming over length of the tube to allow for restoration of patency of said portion of the tube.

8. A method of controlling flow in a fluid line, comprising:

holding the tubing in a bent configuration so as to form the folded portion which seals the tubing;

after the holding, straightening a folded portion of tubing to unseal it; and

placing a restoring member over the straightened folded portion of the tubing to increase patency of a lumen of the tubing,

wherein the holding includes providing a removable holding member which maintains the tubing in a folded state.

9. The method of claim 8, wherein the straightening includes moving the holding member that holds the tubing in the folded state.

10. The method of claim 9, wherein the holding member defines a substantially cylindrical portion which surrounds portions of the tubing on either side of the folded portion.

11. The method of claim 10, wherein the holding member remains movably attached to the tubing after the straightening.

12. The method of claim 8, wherein the restoring member is a tubular element with an internal diameter substantially equal to an outer diameter of the tubing, the tubular element being configured to surround the tubing on either side of the straightened folded portion.

13. The method of claim 12, wherein the restoring member is closely conforming over a length of the tubing to allow for increasing patency of the lumen.

14. The method of claim 8, further comprising, flowing fluid through said tubing to or from a batch container connected thereto.