Method for diagnosing ADHD and related behavioral disorders

• US 8,469,901 B2
• Filed: 04/04/2007
• Issued: 06/25/2013
• Est. Priority Date: 04/04/2006
• Status: Active Grant

• Current Assignee: Mclean Hospital (Mass General Brigham, Inc.)
• Original Assignee: Mclean Hospital (Mass General Brigham, Inc.)
• Inventors: Teicher, Martin H., Ohashi, Kyoko
• Primary Examiner(s): Szmal, Brian
• Assistant Examiner(s): NGUYEN, HUONG Q
• Application Number:
  US11/732,526
• Publication Number:
  US 20080021351A1
• Time in Patent Office: 2,274 Days
• Field of Search: 600/595
• US Class Current: 600/595
• CPC Class Codes: A61B 5/11 Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb for measuring pulse A61B5/02 ;A61B5/1038 takes precedence; motion detection to correct for motion artifacts in physiological signals A61B5/721
• CPC Class Codes: A61B 5/1128 using image analysis A61B5/1127 takes precedence
• CPC Class Codes: A61B 5/168 Evaluating attention deficit, hyperactivity
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence

Abstract

The invention features methods and systems for the diagnosis of ADHD and related disorders. The methods and systems of the invention can also be used to ascertain how much benefit an individual would derive from a particular therapy.

Claims

1. A method of diagnosing ADHD or a related disorder in a subject comprising the steps of:

(i) using a motion analysis device to record movements and produce motion data of said subject and transmitting said motion data to a computer for analysis;

(ii) receiving the results of said analysis, wherein said analysis comprises calculating from said motion data the power spectral density of the oscillations in said movements; and

(iii) on the basis of said spectral density, diagnosing whether said subject has ADHD or a related disorder, wherein said spectral density is calculated over a frequency range between 0.01 and 0.5 Hz.

2. The method of claim 1, wherein said spectral density is calculated over a frequency range between 0.01 and 0.3 Hz.

3. The method of claim 2, wherein said spectral density is calculated over a frequency range between 0.01 and 0.1 Hz.

4. The method of claim 2, wherein said spectral density is calculated over a frequency range between 0.05 and 0.2 Hz.

9. The method of claim 1, 5, or 6, wherein said disorder is ADD, ADHD, or Hyperkinetic Disorder.

10. The method of claim 1, 5, or 6, further comprising continuous performance testing of said subject while recording said movements.

11. The method of claim 1, 5, or 6, wherein step (i) comprises measuring the activity of said subject using an infrared motion analysis system by tracking the movements of said subject'"'"'s head, leg, elbow, shoulder, hand, or foot using a camera.

5. A method of diagnosing ADHD or a related disorder in a subject comprising the steps of:

(i) using a motion analysis device to record movements and produce motion data of said subject and transmitting said motion data to a computer for analysis;

(ii) receiving the results of said analysis, wherein said analysis comprises calculating from said motion data the number of spikes in said movements; and

(iii) on the basis of said number, diagnosing said whether subject has ADHD or a related disorder wherein said spikes are bursts in the rate of said movements by said subject exceeding a threshold amplitude of greater than 1 mm/second.

7. The method of claim 5 or 6, wherein said spikes have an amplitude of greater than 3 mm/second.

8. The method of claim 5, wherein said number of spikes is calculated for two or more different amplitudes.

6. A method of diagnosing ADHD or a related disorder in a subject comprising the steps of:

(i) using a motion analysis device to record movements and produce motion data of said subject and transmitting said motion data to a computer for analysis;

(ii) receiving the results of said analysis, wherein said analysis comprises calculating from said motion data the time intervals between spikes in said movements; and

(iii) on the basis of said time intervals, diagnosing whether said subject has ADHD or a related disorder wherein said spikes are bursts in the rate of said movements by said subject exceeding a threshold amplitude of greater than 1 mm/second.

12. A method for assessing the efficacy of a medicament for the treatment of ADHD or a related disorder in a subject diagnosed with said disorder, said method comprising:

(a) administering said medicament to said subject;

(b) using a motion analysis device to record movements and produce motion data of said subject while medicated and transmitting said motion data to a computer for analysis;

(c) receiving the results of said analysis, wherein said analysis comprises calculating from said motion data the power spectral density of the oscillations in said movements; and

(d) on the basis of said spectral density, determining the effect of said medicament on said subject diagnosed with said disorder, wherein said spectral density is calculated over a frequency range between 0.01 and 0.5 Hz.

13. The method of claim 12, further comprising:

(e) prior to step (a), using a motion analysis device to record movements and produce motion data of said subject while unmedicated and transmitting said motion data to a computer for analysis;

(f) receiving the results of said analysis, wherein said analysis comprises calculating from said motion data the power spectral density of the oscillations in said movements; and

(g) on the basis of said spectral density for step (c) and said spectral density for step (f), determining the effect of said medicament on said subject.

14. A method for assessing the efficacy of a medicament for the treatment of ADHD or a related disorder in a subject diagnosed with said disorder, said method comprising:

(a) administering said medicament to said subject;

(b) using a motion analysis device to record movements and produce motion data of said subject while medicated and transmitting said motion data to a computer for analysis;

(c) receiving the results of said analysis, wherein said analysis comprises calculating from said motion data the number of spikes in said movements; and

(d) on the basis of said number, determining the effect of said medicament on said subject diagnosed with said disorder wherein said spikes are bursts in the rate of said movements by said subject exceeding a threshold amplitude of greater than 1 mm/second.

15. The method of claim 14, further comprising:

(e) prior to step (a), using a motion analysis device to record movements and produce motion data of said subject while unmedicated and transmitting said motion data to a computer for analysis;

(f) receiving the results of said analysis, wherein said analysis comprises calculating from said motion data said number of spikes in said movements; and

(g) on the basis of said number for step (c) and said number for step (f), determining the effect of said medicament on said subject.

16. A method for assessing the efficacy of a medicament for the treatment of ADHD or a related disorder in a subject diagnosed with said disorder, said method comprising:

(a) administering said medicament to said subject;

(b) using a motion analysis device to record movements and produce motion data of said subject while medicated and transmitting said motion data to a computer for analysis;

(c) receiving the results of said analysis, wherein said analysis comprises calculating from said motion data the time intervals between spikes in said movements; and

(d) on the basis of said time intervals, determining the effect of said medicament on said subject diagnosed with said disorder wherein said spikes are bursts in the rate of said movements by said subject exceeding a threshold amplitude of greater than 1 mm/second.

17. The method of claim 16, further comprising:

(e) prior to step (a), using a motion analysis device to record movements and produce motion data of said subject while unmedicated and transmitting said motion data to a computer for analysis;

(f) receiving the results of said analysis, wherein said analysis comprises calculating from said motion data the time intervals between said spikes in said movements; and

(g) on the basis of said time intervals for step (c) and said time intervals for step (f), determining the effect of said medicament on said subject.

18. A system for diagnosing a disorder selected from ADHD or a and related disorders in a subject comprising:

(i) a motion analysis device;

(ii) a device for receiving and storing motion data; and

(iii) a processor provided with a computer program for analyzing said motion data to calculate the power spectral density of the oscillations in said motion over a frequency range between 0.01 and 0.5 Hz; and

(iv) an output providing a diagnosis of ADHD or a related disorder.

21. The system of any of claims 18-20, wherein said motion analysis device comprises a camera for measuring the activity of a subject using infrared light.

19. A system for diagnosing ADHD or a related disorder in a subject comprising:

(i) a motion analysis device;

(ii) a device for receiving and storing motion data;

(iii) a processor provided with a computer program for analyzing said motion data to calculate the number of spikes in said motion; and

(iv) an output providing a diagnosis of ADHD or a related disorder,

wherein said spikes are bursts in the rate of said movements by said subject exceeding a threshold amplitude of greater than 1 mm/second.

20. A system for diagnosing ADHD or a related disorder in a subject comprising:

(i) a motion analysis device;

(ii) a device for receiving and storing motion data; and

(iii) a processor provided with a computer program for analyzing said motion data to calculate the time intervals between spikes in said motion; and

(iv) an output providing a diagnosis of ADHD or a related disorder,

wherein said spikes are bursts in the rate of said movements by said subject exceeding a threshold amplitude of greater than 1 mm/second.