Implantable valve

• US 8,470,022 B2
• Filed: 08/31/2006
• Issued: 06/25/2013
• Est. Priority Date: 08/31/2005
• Status: Active Grant

• Current Assignee: Cook Biotech Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Biotech Incorporated (Cook Group Incorporated)
• Inventors: Johnson, Chad E.
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): WOLF, MEGAN YARNALL
• Application Number:
  US11/513,881
• Publication Number:
  US 20070050014A1
• Time in Patent Office: 2,490 Days
• Field of Search: 623/2.13, 623/2.14, 623/2.17, 623/1.24, 600/36
• US Class Current: 623/1.24
• CPC Class Codes: A61F 2/2415 Manufacturing methods
• CPC Class Codes: A61F 2/2475 Venous valves

Abstract

Described are implantable prosthetic valve devices comprising isolated granulation tissue. Also described are methods of treatment that include implanting at least one of these valves within a body passageway of a patient, for example, within a vein to treat venous insufficiency.

Claims

1. An implantable valve for modifying fluid flow in a body passageway, said valve comprising a frame and at least one valve cusp attached to the frame, the at least one valve cusp having a wall of material in a cusp shape with a first, concave exposed surface and a second, convex exposed surface opposite the first exposed surface, and a wall thickness spanning from said first exposed surface to said second exposed surface, wherein said wall of material consists of isolated granulation tissue grown to and retaining shape memory for said cusp shape, and wherein said isolated granulation tissue is free of additional, non-native crosslinking.

2. The valve of claim 1, wherein said isolated granulation tissue includes mesothelial cells.

3. The valve of claim 1, wherein said isolated granulation tissue includes myofibroblasts.

4. The valve of claim 1, wherein said isolated granulation tissue is decellularized.

5. The valve of claim 1, wherein said isolated granulation tissue is formed in a body cavity.

6. The valve of claim 5, wherein said body cavity is in a human.

7. The valve of claim 5, wherein said body cavity is in a human patient to receive said implantable valve.

8. The valve of claim 1 which is a monocusp valve.

9. The valve of claim 1 which is a multicuspid valve.

10. The valve of claim 1 which is a bicuspid valve.

11. The valve of claim 1 which is a tricuspid valve.

12. The valve of claim 1 configured for implantation as a vascular valve.

13. The valve of claim 1 configured for implantation as a heart valve.

14. The valve of claim 1 configured for implantation as a venous valve.

15. The valve of claim 1, wherein said cusp shape curves in both a longitudinal direction and a lateral direction along said valve cusp.

16. The valve of claim 1, wherein said at least one valve cusp is sutured to said frame.

17. The valve of claim 16, wherein said frame is collapsible.

18. The valve of claim 16, wherein said frame is bioresorbable.

19. The valve of claim 16, wherein said frame comprises a metallic material.

20. The valve of claim 1, wherein said valve includes adaptations to attach said valve to walls of said body passageway.

21. The valve of claim 1, wherein the wall thickness of the entire valve cusp is formed from isolated granulation tissue.

22. A method of treatment comprising implanting at least one implantable valve according to claim 1 within a body passageway of a patient.

23. The method of claim 22, wherein the at least one valve is implanted within a vascular vessel to treat a condition of the vascular system.

24. The method of claim 22, wherein the at least one valve is implanted within a vein to treat venous insufficiency.

25. The method of claim 22, wherein the at least one valve is implanted percutaneously.

26. The method of claim 22, wherein the wall thickness of the entire valve cusp is formed from isolated granulation tissue.

27. The method of claim 22, wherein said isolated granulation tissue has not been treated with a chemical crosslinking agent.