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Particulate materials

  • US 8,470,301 B2
  • Filed: 11/11/2011
  • Issued: 06/25/2013
  • Est. Priority Date: 04/17/2002
  • Status: Expired due to Term
First Claim
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1. A composition of an aerosol formulation, comprising:

  • a particulate active substance of non-micronized, solid particles having a mass median aerodynamic diameter of less than 10 μ

    m, suspended in a hydrofluorocarbon fluid vehicle at a concentration within a range from about 0.2% w/v to about 5% w/v, wherein the aerosol formulation exhibits a flocculation volume of about 85% or greater about 1 minute after mixing the particulate active substance and the hydrofluorocarbon fluid vehicle, and the particulate active substance comprises an alkaloid ergotamine, pharmaceutically acceptable salts thereof, analogues thereof, or derivatives thereof.

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