Processes for preparing piperazinium salts of KMUP and use thereof
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Abstract
A series of monoquarternary piperazium salts including a structure of a formula I or II are provided. In formula I or II, R1, Ra, and RX are as defined in the specification. The monoquarternary piperazium salt of KMUP or piperazine disclosed in the present invention is characterized by being presented in a pro-drug form and having various pharmaceutical functions.
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12 Claims
- 1. A complex compound represented by a structure being
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9. A pharmaceutical composition, comprising :
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an effective amount of one of a KMUP salt and a piperazinium salt; an effective amount of a first compound containing a carboxylic group donated from one selected from a group consisting of a statin, a non-steroid anti-inflammatory (NSAIDs), an anti-allergy drug, an anti-diabetic drug and an anti-asthmatic drug; and an effective amount of a second compound containing a carboxylic group donated from one selected from a group consisting of a statin, a non-steroid anti-inflammatory (NSAIDs), an anti-allergy drug, an anti-diabetic drug and an anti-asthmatic drug. - View Dependent Claims (10, 11, 12)
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Specification