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Vitamin E succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof

  • US 8,470,873 B2
  • Filed: 02/01/2007
  • Issued: 06/25/2013
  • Est. Priority Date: 02/01/2006
  • Status: Active Grant
First Claim
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1. A vitamin E succinate (VES) stabilized oil-in-water emulsion comprising:

  • vitamin E succinate (VES) andoil droplets in an aqueous medium, wherein the oil droplets comprise a substantial portion of a substantially water insoluble pharmacologically active agent, wherein the pharmacologically active agent in the emulsion consists of docetaxel;

    whereinthe average diameter of the droplets being no greater than about 1 micron, wherein the emulsion is stabilized by a submicron suspension of vitamin E succinate (VES), and the emulsion has a zeta potential between −

    20 mV and −

    50 mV.

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