System and method for detecting pulmonary edema based on impedance measured using an implantable medical device during a lead maturation interval

• US 8,473,054 B2
• Filed: 05/28/2009
• Issued: 06/25/2013
• Est. Priority Date: 05/28/2009
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Pillai, Ajit, Xi, Cecilia Qin
• Primary Examiner(s): Patel, Niketa
• Assistant Examiner(s): Flory, Christopher A
• Application Number:
  US12/474,157
• Publication Number:
  US 20100305641A1
• Time in Patent Office: 1,489 Days
• Field of Search: 607/17, 607/27, 607/28, 607/116, 600/547
• US Class Current: 607/17
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

Techniques are provided for use by implantable medical devices such as cardiac resynchronization therapy (CRT) devices for detecting pulmonary edema based on transthoracic impedance sensed using cardiac pacing/sensing leads, wherein detection can be performed while lead maturation occurs. Briefly, the implantable device determines whether the leads are within an initial post-implant interval following implant during which lead maturation generally occurs. The device then detects pulmonary edema or related medical conditions within the patient based on transthoracic impedance using a set of detection parameters adjusted for use during the post-implant interval. Thus, rather than “blanking” impedance data during lead maturation, the device instead detects and processes impedance during this period to identify possible episodes of pulmonary edema so that appropriate measures can be undertaken, such as delivery of warnings or titration of appropriate medications.

Claims

1. A method for use with an implantable medical device for implant within a patient along with at least one lead, the method comprising:

determining whether the lead is within an initial post-implant interval following lead implant during which lead maturation occurs, wherein determining whether the lead is within the initial post-implant interval includes;

determining the duration of the initial post-implant interval by adding a lead maturation period to a long-term average window duration; and

tracking an amount of time since lead implant to determine whether the lead is within the initial post-implant interval;

detecting values representative of transthoracic impedance within the patient using the lead; and

detecting a medical condition within the patient during the initial post-implant interval based on the values representative of transthoracic impedance using a set of detection parameters.

2. The method of claim 1 wherein the duration of the lead maturation period is about one month and the long-term average window duration is initially about two-weeks.

3. The method of claim 1 wherein detecting a medical condition is performed to detect pulmonary edema (PE).

4. The method of claim 1 wherein detecting a medical condition within the patient during the initial post-implant interval includes:

retrieving the set of detection parameters;

adjusting the parameters when the lead is determined to be within the initial post-implant interval; and

detecting a first episode of the medical condition during the initial post-implant interval by applying the adjusted detection parameters to the values representative of transthoracic impedance detected during the initial post-implant interval.

5. The method of claim 4 further comprising detecting a second episode of the medical condition within the patient following the initial post-implant interval by applying non-adjusted detection parameters to the values representative of transthoracic impedance detected after the post-implant interval.

6. A method for use with an implantable medical device for implant within a patient along with at least one lead, the method comprising:

determining whether the lead is within an initial post-implant interval following lead implant during which lead maturation occurs;

detecting values representative of transthoracic impedance within the patient using the lead; and

detecting a medical condition within the patient during the initial post-implant interval based on the values representative of transthoracic impedance using a set of detection parameters, wherein detecting a medical condition within the patient during the initial post-implant interval includes;

retrieving the set of detection parameters;

adjusting the parameters when the lead is determined to be within the initial post-implant interval; and

detecting a first episode of the medical condition during the initial post-implant interval by applying the adjusted detection parameters to the values representative of transthoracic impedance detected during the initial post-implant interval, wherein the set of detection parameters includes a long-term average window duration, a short-term average window duration, and a detection threshold.

7. The method of claim 6 wherein adjusting the parameters for use during the initial post-implant interval is performed to adjust the duration of the long-term average window based on time since implant.

8. The method of claim 7 wherein the duration of the long-term average is adjusted during the initial post-implant interval to increase linearly relative to its retrieved value.

9. The method of claim 7 wherein the duration of the long-term average is adjusted during the initial post-implant interval to increase nonlinearly relative to its retrieved value.

10. The method of claim 7 wherein the duration of the long-term average is adjusted during the initial post-implant interval to increase stepwise relative to its retrieved value by fractional steps.

11. The method of claim 6 wherein adjusting the parameters for use during the initial post-implant interval is performed to adjust the detection threshold based on time since implant.

12. The method of claim 11 wherein the value of the detection threshold is adjusted during the initial post-implant interval to increase linearly relative to its retrieved value.

13. The method of claim 11 wherein the value of the detection threshold is adjusted during the initial post-implant interval to increase nonlinearly relative to its retrieved value.

14. The method of claim 11 wherein the value of the detection threshold is adjusted during the initial post-implant interval to increase stepwise relative to its retrieved value by fractional steps.

15. The method of claim 6 wherein detecting an episode of the medical condition includes:

determining both a long-term average and a short-term average of the values representative of transthoracic impedance during the initial post-implant interval based on adjusted values of the window duration parameters;

accumulating a detection index based on a comparison of the short-term average to the long-term average, wherein the index is increased if the short-term average is below the long-term average; and

detecting the episode of the medical condition by determining whether the index exceeds the detection threshold.

16. A method for use with an implantable medical device for implant within a patient along with at least one lead, the method comprising:

determining whether the lead is within an initial post-implant interval following lead implant during which lead maturation occurs, wherein determining whether the lead is within the initial post-implant interval comprises;

determining the duration of the initial post-implant interval by adding a lead maturation period to a long-term average window duration; and

tracking an amount of time since lead implant to determine whether the lead is within the initial post-implant interval;

detecting values representative of transthoracic impedance within the patient using the lead;

retrieving a set of detection parameters;

adjusting the detection parameters when the lead is within an initial post-implant interval;

detecting a medical condition within the patient during the initial post-implant interval based on the values representative of transthoracic impedance; and

using the set of adjusted detection parameters.

17. The method of claim 16 wherein the set of detection parameters includes a long-term average window duration, a short-term average window duration, and a detection threshold.

18. The method of claim 17 wherein adjusting the detection parameters when the lead is within an initial post-implant interval is performed to adjust the duration of the long-term average window based on time since implant.