Systems and methods for ablating body tissue

• US 8,475,379 B2
• Filed: 11/17/2009
• Issued: 07/02/2013
• Est. Priority Date: 11/17/2008
• Status: Active Grant

• Current Assignee: VytronUS, Inc. (Johnson & Johnson)
• Original Assignee: VytronUS, Inc. (Johnson & Johnson)
• Inventors: Thapliyal, Hira V., Gallup, David A., Arenson, James W., Mohr, Paul, Proulx, Tim, Brommer, Robert A.
• Primary Examiner(s): Jung, Unsu
• Assistant Examiner(s): Selkin, Saurel J
• Application Number:
  US12/620,287
• Publication Number:
  US 20100125198A1
• Time in Patent Office: 1,323 Days
• Field of Search: 600/439
• US Class Current: 600/439
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2090/3782 transmitter or receiver in catheter or minimal invasive instrument
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/445 Details of catheter construction
• CPC Class Codes: A61B 8/4488 the transducer being a phased array
• CPC Class Codes: A61B 8/4494 characterised by the arrangement of the transducer elements devices for short-range imaging using particular transducer elements arrangements under G01S15/8909; arrangements of transducers in generation of mechanical vibrations of infrasonic, sonic or ultrasonic frequency B06B1/0607
• CPC Class Codes: A61N 7/022 intracavitary
• CPC Class Codes: G01S 15/8952 using discrete, multiple frequencies
• CPC Class Codes: G01S 15/899 Combination of imaging systems with ancillary equipment

Abstract

A transducer subassembly with combined imaging and therapeutic capabilities is disclosed. The subassembly includes heat sinks that are configured to maintain the transducer at a low operating temperature so that the transducer operates at high efficiency and also can handle a wider range of frequencies. The subassembly is also configured to allow cooling fluid to flow past the transducer element. One heat sink in the subassembly also acts as an acoustic matching layer and another heat sink acts as a backing. Alternatively, the second heat sink which acts as a backing is optional. The transducer is configured to transmit at one power level for imaging, and at a second power level for ablating. The transducer may comprise sub-elements transmitting at different power levels. The subassembly may be operated at one power level for imaging and a second power level for ablating.

Claims

1. A transducer system comprising:

a transducer element comprising a proximal surface and a distal surface;

a first heat sink attached to the distal surface of the transducer element;

a second heat sink attached to the proximal surface of the transducer element;

and a base coupled to the first and second heat sinks, wherein the base is configured to allow fluid flow past the transducer element for cooling the proximal and distal surfaces of the transducer element, and

wherein the second heat sink comprises a second bonding portion and a second bent portion, and wherein the second bonding portion is bonded to the proximal surface of the transducer, and wherein the second bent portion protrudes proximally from the transducer element, thereby conducting heat away from the proximal surface of the transducer element.

2. The system of claim 1, further comprising a tubular jacket configured to house the base, the transducer element, and the first and second heat sinks, wherein the tubular jacket comprises at least one fluid exit port configured to allow fluid to exit the tubular jacket.

3. The system of claim 1, wherein the first heat sink comprises a first bonding portion and a first bent portion, wherein the first bonding portion is bonded to the distal surface of the transducer, and wherein the first bent portion protrudes proximally from the transducer element, thereby conducting heat away from the distal surface of the transducer element.

4. The system of claim 3 wherein the first bonding portion comprises a material whose composition and dimension provides an acoustically matching layer on the distal surface of the transducer element.

5. The system of claim 4, wherein the first bonding portion is a material chosen from the group consisting of aluminum, graphite, metal-filled graphite, ceramic, an amalgam of graphite and copper or tungsten, and an epoxy-filled metal.

6. The system of claim 5, wherein the bonding portion is in electrical and thermal communication with the distal surface of the transducer element.

7. The system of claim 6, wherein the electrical communication between the bonding portion and the distal surface is established by the direct contact between the bonding portion and the distal surface.

8. The system of claim 7, wherein the direct contact is controlled by surface roughness of the bonding portion and the distal surface.

9. The system of claim 3, wherein the first and second bonding portions comprise perforations such that the first bonding portion is acoustically matched and the second bonding portion is acoustically mismatched to the acoustic impedance of the transducer element.

10. The system of claim 3, wherein the first bent portion is directed transversely to the transducer element.

11. The system of claim 1, wherein the second bonding portion comprises a material whose composition is acoustically mismatched to an acoustic impedance of the transducer element, thereby providing a reflective backing layer on the proximal surface of the transducer element.

12. The system of claim 1, further comprising an air pocket disposed between the proximal surface of the transducer and the second heat sink.

13. The system of claim 1, wherein the second bonding portion comprises copper.

14. The system of claim 1, wherein the transducer element comprises a flat circular disc.

15. The system of claim 1, wherein the transducer element operates at a first power level in a first frequency range and a second power level in a second frequency range.

16. The system of claim 15, wherein the first frequency range is used for ultrasonically imaging tissue and the second frequency range is used for creating tissue lesions.

17. The system of claim 16, wherein the first frequency range is 5 MHz to 30 MHz and the second frequency range is 10 to 18 MHz.

18. The system of claim 1, further comprising an elongate flexible shaft having a proximal end and a distal end, and wherein the transducer is disposed adjacent the distal end of the shaft.

19. The system of claim 1, further comprising a cooling fluid in fluid communication with the transducer.

20. The system of claim 1, further comprising a temperature sensor adjacent the transducer for monitoring temperature.

21. The system of claim 1, wherein the second bent portion is directed transversely to the transducer.

22. A method of ablating tissue, said method comprising:

introducing an ablation device into a patient, wherein the device comprises a transducer element comprising a proximal surface and a distal surface; and

a first heat sink attached to the distal surface of the transducer element; and

a second heat sink attached to the proximal surface of the transducer element, wherein the second heat sink comprises a second bonding portion and a second bent portion, and wherein the second bonding portion is bonded to the proximal surface of the transducer, and wherein the second bent portion protrudes proximally from the transducer element, thereby conducting heat away from the proximal surface of the transducer element; and

a base coupled to the first and second heat sinks, wherein the base is configured to allow fluid flow past the transducer element for cooling the proximal and distal surfaces of the transducer element; and

wherein the transducer element is configured to operate at a first power level and at a second power level, wherein the first power level is used for ultrasonically imaging tissue and identifying a target tissue, and the second power level is used for ablating the target tissue;

operating the transducer element at the first power level to image a portion of the tissue and identify the target tissue, and at the second power level to ablate the target tissue; and

cooling the surfaces of the ultrasound transducer.

23. The method of claim 22, further comprising monitoring temperature of the fluid and adjusting fluid flow based on the monitored temperature.

24. The method of claim 22, wherein the transducer element comprises first and second portions, wherein the first portion is configured to operate at the first power level and the second portion is configured to operate at the second power level.

25. The method of claim 24, wherein the first portion is operated at the first power level concurrently with operation of the second portion at the second power level.

26. The method of claim 22, wherein the introducing step comprises passing the ablation device transseptally across a septal wall of the patient'"'"'s heart.

27. The method of claim 22, wherein the introducing step comprises positioning the ablation device into a left atrium of the patient'"'"'s heart.

28. The method of claim 27, wherein there is no contact between the ultrasound transducer and the target tissue.

29. The method of claim 22, further comprising monitoring temperature of the transducer element and adjusting either the first or the second power level based on the monitored temperature.

30. The method of claim 22, wherein the first heat sink comprises a first bonding portion and a first bent portion, wherein the first bonding portion is bonded to the distal surface of the transducer, and wherein the first bent portion protrudes proximally from the transducer element, thereby conducting heat away from the distal surface of the transducer element.

31. The method of claim 22, wherein the second bent portion is directed transversely to the transducer element.