Osmotic devices and methods for diuretic therapy

• US 8,475,400 B2
• Filed: 01/09/2012
• Issued: 07/02/2013
• Est. Priority Date: 07/02/2007
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Shuros, Allan Charles, Mokelke, Eric A., Kane, Michael John
• Primary Examiner(s): Wiest, Philip R
• Application Number:
  US13/346,485
• Publication Number:
  US 20120109038A1
• Time in Patent Office: 540 Days
• Field of Search: 604 601- 616, 604/31, 604/82, 604/96.01, 604/97.07, 604/98.01, 604/99.02, 604/99.04, 604/192, 604/523, 604/915, 604/920, 604/103.01, 600/585
• US Class Current: 604/6.09
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/12036 partial occlusion
• CPC Class Codes: A61B 17/12099 characterised by the location of the occluder
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61F 2250/0003 having an inflatable pocket filled with fluid, e.g. liquid or gas

Abstract

Embodiments of the invention are related to devices and methods for modulating renal function, amongst other things. In an embodiment, the invention includes a method of modulating renal function in a patient including implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane and configured to expand or contract based on the passage of a fluid across the semi-permeable membrane. Other aspects and embodiments are provided herein.

Claims

1. A method of modulating renal function in a patient comprising:

implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane, the occlusive device configured to expand or contract based on the passage of a fluid across the semi-permeable membrane; and

expanding the occlusive device in response to decreases in osmolality of a bodily fluid;

wherein expanding the occlusive device results in occluding a renal lymphatic vessel with the occlusive device; and

contracting the occlusive device in response to increases in osmolality of the bodily fluid.

2. The method of claim 1, comprising implanting the occlusive device inside a renal lymphatic vessel of the patient.

3. The method of claim 1, comprising implanting the occlusive device outside of a renal lymphatic vessel of the patient.

4. The method of claim 1, the occlusive device configured to expand in response to decreases in osmolality of a bodily fluid within a renal lymphatic vessel.

5. The method of claim 1, the occlusive device configured to contract in response to increases in osmolality of a bodily fluid within a renal lymphatic vessel.

6. The method of claim 1, the occlusive device defining an enclosed volume.

7. The method of claim 6, further comprising inserting a solution comprising a solvent and a solute into the enclosed volume.

8. A method of treating a hypervolemic state including heart failure decompensation and/or hypertension comprising:

implanting an occlusive device in the patient, the occlusive device comprising a semi-permeable membrane, the occlusive device configured to expand or contract based on the passage of a fluid across the semi-permeable membrane; and

expanding the occlusive device in response to decreases in osmolality of a bodily fluid;

wherein expanding the occlusive device results in occluding a renal lymphatic vessel with the occlusive device; and

contracting the occlusive device in response to increases in osmolality of the bodily fluid.

9. The method of claim 8, comprising implanting the occlusive device inside a renal lymphatic vessel of the patient.

10. The method of claim 8, comprising implanting the occlusive device outside of a renal lymphatic vessel of the patient.

11. The method of claim 8, the occlusive device configured to expand in response to decreases in osmolality of a bodily fluid within a renal lymphatic vessel.

12. The method of claim 8, the occlusive device configured to contract in response to increases in osmolality of a bodily fluid within a renal lymphatic vessel.

13. The method of claim 8, the occlusive device defining an enclosed volume.

14. The method of claim 13, further comprising inserting a solution comprising a solvent and a solute into the enclosed volume.