Chemical and biological sensors, systems and methods based on radio frequency identification

• US 8,475,716 B2
• Filed: 10/18/2012
• Issued: 07/02/2013
• Est. Priority Date: 10/26/2005
• Status: Active Grant

• Current Assignee: GE Infrastructure Technology, LLC (General Electric Company)
• Original Assignee: General Electric Company
• Inventors: Potyrailo, Radislav Alexandrovich, Morris, William Guy
• Primary Examiner(s): WHITE, DENNIS MICHAEL
• Application Number:
  US13/654,587
• Publication Number:
  US 20130052084A1
• Time in Patent Office: 257 Days
• Field of Search: 422/52, 422/73, 422/82.01, 422/82.05, 422/82.08, 422/82.09, 422/82.11, 422/99, 422/102, 422/407, 422/501, 422/502, 422/503, 422/504, 436/164, 436/177, 436/43, 436/63, 506/30, 435/29, 435/4, 435/6, 435/7.1, 250/214.1, 250/251, 250/576, 530/408, 714/752
• US Class Current: 422/82.02
• CPC Class Codes: G01N 27/3275 Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
• CPC Class Codes: G01N 27/3278 involving nanosized elements, e.g. nanogaps or nanoparticles nanopores G01N33/48721; magnetic beads G01N27/745
• CPC Class Codes: G06K 19/0717 the sensor being capable of sensing environmental conditions such as temperature history or pressure
• CPC Class Codes: G06K 19/07749 the record carrier being capable of non-contact communication, e.g. constructional details of the antenna of a non-contact smart card
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/25375 Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Abstract

An embodiment of the invention described herein is directed to a detection system utilizing at least one radiofrequency identification (RFID) sensor comprising: an RFID sensor comprising: a substrate; an antenna; a sensor material selected to be sensitive to one of chemical or biological environment; and a reader, wherein said reader is configured to measure a signal in the form of a complex impedance from said RFID tag wherein said signal comprises a plurality of frequencies and a frequency shift of the maximum of the imaginary part of the complex impedance, a frequency shift of the minimum of the imaginary part of the complex impedance, a frequency shift of the maximum of the real part of the complex impedance, and changes in magnitude of the real part of the complex impedance; and, wherein said complex impedance is related to a nature and a concentration of analyte species derived from multivariate analysis.

Claims

1. A detection system utilizing at least one radiofrequency identification (RFID) sensor comprising:

an RFID sensor comprising;

a substrate;

an antenna disposed upon said substrate;

a sensor material disposed adjacent to at least a portion of the antenna and the sensor material being selected to be sensitive to one of chemical or biological environment; and

a reader for receiving and processing signals from said RFID tag, wherein said reader is configured to measure a signal in the form of a complex impedance from said RFID tag wherein said signal comprises a plurality of frequencies and changes in the real and imaginary parts of the complex impedance;

wherein said changes in the real and imaginary parts of the complex impedance comprise a frequency shift of the maximum of the imaginary part of the complex impedance (F1 shift), a frequency shift of the minimum of the imaginary part of the complex impedance (F2 shift), a frequency shift of the maximum of the real part of the complex impedance (Fp), and changes in magnitude of the real part of the complex impedance (Zp); and

,

wherein said complex impedance is related to a nature and a concentration of analyte species and is derived from multivariate analysis.

2. The detection system of claim 1, wherein said reader includes a multivariate pattern recognition subcomponent.

3. The detection system of claim 1, wherein changes in the real and imaginary parts of the complex impedance include a plurality of frequency shifts and changes in magnitude corresponding to real and imaginary parts of the complex impedance.

4. The detection system of claim 1, wherein said reader is configured to periodically read and quantify the signal from the RFID sensor.

5. The detection system of claim 1, wherein the plurality of changes in magnitude corresponding to the real and imaginary parts of the complex impedance are used to provide position independent responses from said RFID sensor.

6. The detection system of claim 1, wherein said sensor material comprises inorganic, polymeric, biological, metallic, semiconducting, composite, structured materials, and materials which are capable of changing an electrical environment when appropriately stimulated.

7. The detection system of claim 1, wherein said sensor material is sensitive to a biospecific entity.

8. The detection system of claim 7, wherein said at least one biospecific entity comprises at least one from the group consisting of a peptide, a nucleic acid, and an antibody.

9. The detection system of claim 1, wherein said reader is configured to periodically read and quantify the signal from the RF sensor.

10. A detection system comprising:

a radiofrequency (RF) wireless sensor;

a sensor reader configured to transmit RF energy to said RF wireless sensor, configured to receive and process signals from said RF wireless sensor, and configured to measure a plurality of frequency shifts and changes in magnitude corresponding to real and imaginary parts of the complex impedance of said RF wireless sensor at least three frequencies, wherein said frequency shifts comprise a frequency shift of the maximum of the imaginary part of the complex impedance (F1 shift), a frequency shift of the minimum of the imaginary part of the complex impedance (F2 shift), a frequency shift of the maximum of the real part of the complex impedance (Fp) and a magnitude of the real part of the complex impedance (Zp); and

,

a multivariate signal processor that derives the concentration of at least one species of interest from multivariate analysis of the measured and computed parameters of frequency shifts and changes in the magnitude.

11. The detection system of claim 10, wherein said sensor reader is configured to measure at least two parameters from which a signal related to a nature and concentration of analyte species is derived.

12. The detection system of claim 11, wherein said signal is derived from multivariate analysis of the at least two parameters.

13. The detection system of claim 10, wherein said sensor reader is configured to measure at least three parameters from which a signal related to a nature and concentration of analyte species is derived.

14. The detection system of claim 10, wherein said sensor reader is configured to measure at least four parameters from which a signal related to a nature and concentration of analyte species is derived.

15. The detection system of claim 10, wherein said RF wireless sensor comprises:

a substrate;

an antenna disposed upon said substrate; and

,

a sensor material sensitive to biospecific or chemical entity disposed over at least a portion of said substrate.

16. The detection system of claim 10, wherein the detection system is configured to provide a quantification of a concentration of the at least one species is independent of the relative position of said the sensor reader in relation to said RF wireless sensor.

17. The detection system of claim 10, wherein said sensor material comprises inorganic, polymeric, biological, metallic, semiconducting, composite, structured materials, and materials which are capable of changing an electrical environment when appropriately stimulated.

18. The detection system of claim 10, wherein said sensor reader includes a multivariate pattern recognition subcomponent.