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Baclofen formulation in a polyorthoester carrier

  • US 8,475,823 B2
  • Filed: 04/17/2009
  • Issued: 07/02/2013
  • Est. Priority Date: 04/18/2008
  • Status: Active Grant
First Claim
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1. An implantable drug depot useful for reducing or treating pain in a patient in need of such treatment, the drug depot comprising:

  • a polyorthoester in an amount of about 95 to 99 wt. % based on the total weight of the drug depot, the polyorthoester having a viscosity of about 500 to 10,000 centipoises and prepared from trans-cylcohexanedimethanol, 1,6-hexanediol, and diethyltartrate;

    baclofen in an amount of about 1 to 5 wt. % based on the total weight of the drug depot and having a particle size of between about 5 μ

    m to 50 μ

    m;

    magnesium oxide; and

    at least one of sorbitane tristearate, sorbitane trioleate, poloxamer 407, sorbital, cyclodextrin, maltodextrin, or poloxamer 188,wherein the drug depot is adapted to be administered intraspinally in the patient to reduce or treat pain, has a modulus of elasticity in the range of about 2×

    104 to about 5×

    105 dynes/cm2 after the drug depot is administered at the site, and capable of releasing baclofen for a period of 30 to 180 days after administration; and

    the polyorthoester is capable of degrading in 200 days or less after the drug depot is administered at the site.

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