Methods of activating a melanocortin-4 receptor pathway in obese subjects
First Claim
1. A method of activating a melanocortin-4 receptor (MC4R) pathway in an obese subject, the method comprising:
- (a) performing a first intervention on a subject, wherein the first intervention is a non-surgical procedure;
(b) measuring energy expenditure of the subject to measure MC4R pathway activation in response to the first intervention; and
(c) performing a second intervention that activates the melanocortin receptor pathway, wherein the second intervention is chosen based on the measured energy expenditure and appropriate for the subject to increase energy expenditure, and wherein the first intervention is different from the second intervention.
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Abstract
Methods and therapeutics are provided for treating metabolic disorders by activation of melanocortin signaling pathways. Generally, the methods and therapeutics can induce activation of melanocortin receptor signaling to increase energy expenditure and induce weight loss. In one embodiment, a method for performing a diagnostic procedure can be chosen, energy expenditure then assess in light of the diagnostic procedure and a definitive procedure(s) can be selected dependent on the outcome of the energy assessment. In another embodiment, a diagnostic procedure can be chosen to activate melanocortin receptor pathways, energy expenditure can be assessed and a definitive procedure(s) can be chosen that selectively and optimally activate melanocortin receptor pathways.
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Citations
20 Claims
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1. A method of activating a melanocortin-4 receptor (MC4R) pathway in an obese subject, the method comprising:
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(a) performing a first intervention on a subject, wherein the first intervention is a non-surgical procedure; (b) measuring energy expenditure of the subject to measure MC4R pathway activation in response to the first intervention; and (c) performing a second intervention that activates the melanocortin receptor pathway, wherein the second intervention is chosen based on the measured energy expenditure and appropriate for the subject to increase energy expenditure, and wherein the first intervention is different from the second intervention. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of activating a melanocortin-4 receptor pathway in an obese subject, the method comprising:
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(a) performing a first intervention on a subject, wherein the first intervention is a non-surgical procedure; and
;(b) performing a second intervention that is distinct from the first intervention to increase energy expenditure and activate the melanocortin receptor pathway. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
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17. A method of activating a melanocortin-4 receptor pathway to induce weight loss in an obese subject, the method comprising:
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(a) performing a first intervention on a subject to affect the MC4R pathway; (b) performing a second intervention to increase energy expenditure and activate the MC4R pathway to induce weight loss, and wherein the first intervention is different from the second intervention.
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18. A method of activating a melanocortin-4 receptor pathway to induce weight loss in an obese subject, comprising:
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(a) performing a first intervention on a subject to affect the MC4R pathway; and (b) performing a bariatric surgery to increase energy expenditure and activate the MC4R pathway to induce weight loss, and wherein the first intervention is different from the second intervention. - View Dependent Claims (19, 20)
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Specification