Visualization of electrophysiology data

• US 8,478,393 B2
• Filed: 11/10/2009
• Issued: 07/02/2013
• Est. Priority Date: 11/10/2008
• Status: Active Grant

• Current Assignee: CardioInsight Technologies Inc. (Medtronic Plc)
• Original Assignee: CardioInsight Technologies Inc. (Medtronic Plc)
• Inventors: Ramanathan, Charulatha, Wodlinger, Harold M., Jia, Ping, Gasparakis, Harris, Arless, Steven G., Anderson, John E., Bhojwani, Soniya
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): CAREY, MICHAEL JAMES
• Application Number:
  US13/128,123
• Publication Number:
  US 20120101398A1
• Time in Patent Office: 1,330 Days
• Field of Search: 600/523, 600/508, 600/509
• US Class Current: 600/523
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/339 Displays specially adapted therefor
• CPC Class Codes: A61B 5/347 Detecting the frequency distribution of signals
• CPC Class Codes: A61B 5/367 Electrophysiological study [EPS], e.g. electrical activation mapping or electro-anatomical mapping
• CPC Class Codes: A61B 5/726 using Wavelet transforms
• CPC Class Codes: A61B 5/7475 User input or interface means, e.g. keyboard, pointing device, joystick

Abstract

A method for visualization of electrophysiology information can include storing electroanatomic data (14) in memory, the electroanatomic data representing electrical activity on a surface of an organ over a time period. An interval within the time period is selected in response to a user selection (28). Responsive to the user selection of the interval, a visual representation (26) of physiological information for the user selected interval is generated by applying at least one method to the electroanatomic data (14). The visual representation (26) is spatially represented on a graphical representation of a predetermined region of the surface of the organ.

Claims

1. A method for visualization of electrophysiology information, comprising:

applying an inverse method to compute electroanatomic data that represents electrical activity on a surface of an organ over a time period for a predetermined region of the surface of the organ based on geometry data and electrical data for the patient, the electrical data being acquired for the patient via non-invasive body surface electrodes;

storing the electroanatomic data in memory;

selecting an interval within the time period in response to a user selection via a user interface, wherein the user selection specifies the interval with respect to a representation of a waveform of electrical activity for a given location on the surface of the organ that is generated based on the application of the inverse method;

responsive to the user selection of the interval, generating a visual representation of physiological information for the user selected interval by applying at least one other method to the electroanatomic data, the visual representation being spatially represented on a graphical representation of a corresponding region of the surface of the organ.

2. The method of claim 1, wherein the at least one method is programmed to compute an activation time for each of a plurality of points on the predetermined region of the surface of the organ according to the user selected interval.

3. The method of claim 2, wherein the at least one method is programmed to compute the activation time by performing wavelet analysis on the electroanatomic data, corresponding to at least one respective point on the predetermined region of the surface of the organ, for the user selected interval.

4. The method of claim 2, further comprising:

receiving a user input that modifies the user selected interval;

re-applying the at least one other method to the electroanatomic data to compute the activation time for each the plurality of points according to the modified user selected interval; and

dynamically modifying the visual representation based on the re-application of the at least one method.

5. The method of claim 2, wherein a plurality of activation times are computed for each of the plurality of points, the method further comprising:

determining a cycle length between sequential activation times for each of the plurality of points; and

generating the visual representation as spatial map indicative of at least one of cycle length and a number activation times for each of the plurality of points.

6. The method of claim 2, further comprising setting a user-defined cycle length in response to a user input;

and

generating the visual representation as a map superimposed on the predetermined region of the surface of the organ based on an auto-correlation of the user-defined cycle length and the activation times computed for each the plurality of points.

7. The method of claim 1, wherein the at least one method is programmed to analyze frequency for a plurality of points on the predetermined region of the surface of the organ by computing a frequency spectrum for each the plurality of points according to the user selected interval.

8. The method of claim 7, further comprising:

receiving a user input that modifies the user selected interval;

re-applying the at least one method to the electroanatomic data to compute the frequency spectrum for each the plurality of points according to the modified user selected interval; and

dynamically modifying the visual representation based on the re-application of the at least one method.

9. The method of claim 7, further comprising determining a dominant frequency in the frequency spectrum for each the plurality of points.

10. The method of claim 9, further comprising:

determining an indication of regularity for each dominant frequency for the plurality of points; and

generating the visualization as a spatial map based on the indication of regularity for each of the plurality of points, the spatial map being superimposed on the predetermined region of the surface of the organ.

11. The method of claim 1, further comprising:

receiving a user input that modifies the user selected interval; and

dynamically modifying the visual representation according to the modified user selected interval.

12. The method of claim 1, further comprising selecting the at least one method in response to a user selection input, wherein the at least one method is selected from a set of preprogrammed methods programmed to determine activation time, frequency spectrum information, voltage potential, and electrogram fractionation, respectively.

13. The method of claim 1, further comprising:

receiving a user input that defines location data corresponding to a user the given location on the surface of the organ, at least one virtual electrode being represented on the graphical representation of the corresponding region of the surface of the organ; and

generating a separate visual representation of electrophysiological data for each at least one virtual electrode based on application of the least one other method to the location data and the electroanatomic data, the separate visualization being concurrently displayed with the representation that is spatially represented on the graphical representation of the corresponding region of the surface of the organ.

14. The method of claim 13, wherein the visual representation comprises a graphical representation of an electroanatomic map, the method further comprising superimposing a graphical representation of the at least one virtual electrode on the interactive graphical representation of the predetermined region of the surface of the organ in response to the receiving of the user input.

15. The method of claim 1, wherein the user selected interval defines a start time and an end time that span the time interval visualized in the representation of the waveform of electrical activity for the given location on the surface of the organ, the method further comprising dynamically modifying the visual representation in an animated manner to represent temporal changes in the physiological information spatially depicted by the graphical representation of the predetermined region of the surface of the organ.

16. The method of claim 15, further comprising generating an indication of a current time visualized in the representation of the waveform of electrical activity for the given location on the surface of the organ, the current time identifying a time in the user selected interval corresponding to the dynamically modified the visual representation.

17. The method of claim 16, wherein the interval is selected from an interactive graphical representation of temporal electrophysiology information for at least one point on the predetermined region of the surface of the organ, the indication of current time further comprising a graphical element that is displayed at a position in the graphical representation of temporal electrophysiology information to indicate the current time.

18. The method of claim 17, further comprising automatically repeatedly traversing the interval between the start time and the stop time and dynamically modifying the visual representation during each traversal of the interval.

19. The method of claim 18, wherein the traversing further comprises traversing in a reverse temporal direction from the end time of the interval to the start time of the interval.

20. The method of claim 1, wherein the graphical representation of the predetermined region of the surface of the organ comprises a three-dimensional representation of the surface of a patient'"'"'s heart, the visual representation comprising a corresponding three-dimensional representation of electrogram morphology for the patient'"'"'s heart.

21. The method of claim 1, further comprising preprocessing electrical data acquired from a patient, the electroanatomic data being derived from the acquired electrical data.

22. The method of claim 21, wherein the selected interval is an analysis interval and wherein the preprocessing further comprises selecting at least one sample interval for the acquired electrical data, the electroanatomic being generated according to the electrical data acquired for the at least one sample interval, the visual representation of physiological information for the user selected interval being generated by applying the at least one other method to the electroanatomic data that is generated according to the at least one sample interval, such that the visual representation is variable and responsive to modifications in the analysis interval based on the user selection thereof, while the at least one sample interval remains fixed.

23. The method of claim 22, wherein the at least one sample interval comprises multiple non-temporally contiguous sample intervals, the method further comprising aggregating the acquired electrical data for each of the multiple non-temporally contiguous sample intervals to provide a spliced set of electrical data, the electroanatomic data being generated based on the spliced set of electrical data.

24. The method of claim 22, wherein the at least one method is programmed to analyze frequency for a plurality of points on the predetermined region of the surface of the organ by computing a frequency spectrum for each the plurality of points according to the user selected interval.

25. The method of claim 1, wherein the at least one method is programmed to determine a recovery time for each of a plurality of points on the predetermined region of the surface of the organ according to the user selected interval, such that the visual representation spatially represents the recovery time on the graphical representation of the predetermined region of the surface of the organ.

26. The method of claim 25, wherein the at least one method is further programmed to compute an activation time for each of the plurality of points on the predetermined region of the surface of the organ according to the user selected interval, the method further comprising computing an activation recovery interval based on the recovery time and the activation time for each of the plurality of points on the predetermined region of the surface of the organ.

27. The method of claim 5, further comprising computing statistical information characterizing at least one of a number of activations for each of the plurality of points and spatially representing the computed statistical information as at least one of a number activations, a minimum of the computed cycle length, a maximum of the computed cycle length and a mean cycle length for each of the plurality of points.

37. The method of claim 1, wherein the geometry data comprises at least one of a generic representation of the organ or a patient-specific representation of the organ derived from imaging data for the patient.

28. A system for visualization of physiological information, comprising:

means for storing electroanatomic data in memory, the electroanatomic data representing electrical activity on a surface of an organ over a time period, the electroanatomic data representing electrical activity on a surface of an organ over a time period, wherein the electroanatomic data for the predetermined region of the surface of the organ is computed by applying an inverse method based on patient electrical data for the patient acquired via non-invasive body surface electrodes and geometry data;

means for selecting an interval within the time period in response to a user selection;

means for applying at least one other method to the electroanatomic data for the user selected interval in response to the user selection of the interval and for generating output data; and

means for generating a visual representation of physiological information for the user selected interval based on the output data, the visual representation being spatially represented on a graphical representation of a predetermined region of the surface of the organ.

29. A non-transitory computer readable medium having instructions for performing a method comprising:

storing electroanatomic data in memory, the electroanatomic data representing electrical activity on a surface of an organ over a time period, wherein the electroanatomic data for the predetermined region of the surface of the organ is computed by applying an inverse method based on patient electrical data for the patient acquired via non-invasive body surface electrodes and geometry data, wherein the electroanatomic data corresponds to simultaneous electrical activity that is time indexed over the time period for each of a plurality of points distributed across the predetermined region of the surface of the organ;

selecting an interval within the time period in response to a user selection, wherein the user selection specifies the interval with respect to a waveform representing electrical activity for a given location on the surface of the organ corresponding to the electroanatomic data; and

generating a visual representation of physiological information based on the user selected interval by applying at least one other method to the electroanatomic data, the visual representation being spatially represented on a graphical representation of a corresponding region of the organ.

30. The medium of claim 29, wherein the method further comprises:

receiving a user input to select the given location on the graphical representation of the corresponding region of the organ, the electrical activity represented by the waveform being generated for the given location in response to the user input to enable the user selection of the interval with respect to the waveform.

31. The medium of claim 29, wherein the geometry data comprises at least one of a generic representation of the organ or a patient-specific representation of the organ derived from imaging data for the patient.

32. A non-transitory computer readable medium having instructions for performing a method comprising:

preprocessing electrical data acquired from a patient, the preprocessing including selecting at least one sample interval for the acquired electrical data in response to a user input;

generating electroanatomic data from the acquired electrical data for the selected at least one sample interval, the electroanatomic data representing electrical activity on a surface of an organ over a time period defined by the at least one sample interval;

selecting an analysis interval within the time period in response to a user selection via a user interface, wherein the user selection specifies the analysis interval with respect to a representation of a waveform of electrical activity for a given location on the surface of the organ;

responsive to the selection of the analysis interval, generating a visual representation of physiological information for the analysis interval by applying at least one method to the electroanatomic data that is generated based on the acquired electrical data for the at least one sample interval, such that the visual representation is variable and responsive to modifications in the analysis interval based on the user selection thereof while the at least one sample interval remains fixed, the visual representation of physiological information for the analysis interval being spatially represented on a graphical representation of a corresponding region of the surface of the organ.

33. The medium of claim 32, wherein the at least one sample interval comprises multiple non-temporally contiguous sample intervals, the method further comprising aggregating the acquired electrical data for each of the multiple non-temporally contiguous sample intervals to provide a spliced set of electrical data, the electroanatomic data being generated based on the spliced set of electrical data.

34. The medium of claim 32, wherein the method further comprises:

selecting the given location on the graphical representation of the corresponding region of the organ in response to a user input;

representing a virtual electrode for the given location on the graphical representation of the corresponding region of the organ, the electrical activity represented by the waveform being generated for the given location on the surface of the organ in response to the user input to enable the user selection of the interval with respect to the waveform.

35. The medium of claim 32, wherein the method further comprises:

applying an inverse method to compute the electroanatomical data for the predetermined region of the surface of the organ based on patient electrical data acquired for the patient via non-invasive body surface electrodes and geometry data acquired for the patient, such that the computed electroanatomical data corresponds to simultaneous electrical activity that is time indexed over the time period for each of the plurality of points distributed across the predetermined region of the surface of the organ, the at least one method being applied to the computed electroanatomical data.

36. The medium of claim 35, wherein the geometry data comprises at least one of a generic representation of the organ or a patient-specific representation of the organ derived from imaging data for the patient.