Determining intercardiac impedance

• US 8,478,402 B2
• Filed: 10/31/2008
• Issued: 07/02/2013
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Wahlstrand, John D., Denison, Timothy J., Santa, Wesley A.
• Primary Examiner(s): Patel, Niketa
• Assistant Examiner(s): FAIRCHILD, MALLIKA DIPAYAN
• Application Number:
  US12/263,346
• Publication Number:
  US 20100114223A1
• Time in Patent Office: 1,705 Days
• Field of Search: 607/7, 607/8, 607/28, 600/547
• US Class Current: 607/8
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive
• CPC Class Codes: A61B 5/7217 of noise originating from a therapeutic or surgical apparatus, e.g. from a pacemaker
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

A system and method for determining complex intercardiac impedance to detect various cardiac functions are disclosed involving a signal generator means for providing an adjustable direct current signal, a modulator for modulating the adjustable direct current signal to produce a modulated signal, at least one electrode for propagating the modulated signal across a myocardium, at least one sensor for detecting an outputted modulated signal from the myocardium, and at least one circuit to reduce the influence of process noise (aggressors) in the outputted modulated signal. The at least one circuit comprises an amplifier, a demodulator, and an integrator. The amplitude and phase of the final outputted modulated signal indicate the complex impedance of the myocardium. Changes in the complex impedance patterns of the myocardium provide indication of reduced oxygen and blood flow to the myocardium. The apparatus can be employed in implantable devices, including cardiac pacemakers and implantable cardioverter defibrillators.

Claims

1. A method comprising:

propagating a modulated signal across a myocardium;

detecting an outputted modulated signal from the myocardium;

using at least one circuit to reduce the influence of process noise in the outputted modulated signal, wherein the at least one circuit reduces the influence of process noise by at least;

amplifying the outputted modulated signal to produce a second outputted modulated signal;

demodulating the second outputted modulated signal to produce a third outputted modulated signal; and

passing the third outputted modulated signal through an integrator to produce a fourth outputted modulated signal;

determining an amplitude and phase of the fourth outputted modulated signal, the amplitude and the phase indicating a complex impedance of the myocardium;

monitoring the indication of complex impedance for complex impedance patterns of the myocardium; and

based on changes in complex impedance patterns of the myocardium, providing an indication of cardiac function, wherein the cardiac function is at least one of contractility, capture detection, atrium-ventricle optimization, right ventricular function, left ventricular function, cardiac output, or right to left ventricular synchronization.

2. The method of claim 1, wherein the method further comprises:

providing a direct current signal, wherein the direct current signal is adjustable; and

modulating the adjustable direct current signal to produce the modulated signal.

3. The method of claim 2, wherein the modulated signal has a nominal frequency of approximately 4 kilohertz to prevent interference with functions of other implanted devices.

4. The method of claim 2, wherein the method further comprises:

providing an indication of an ischemic event based on changes in complex impedance patterns of the myocardium;

generating a signal when the ischemic event is indicated, wherein the signal contains an alert message; and

transmitting the signal.

5. The method of claim 2, wherein the method is employed with at least one implantable medical device (IMD).

6. The method of claim 5, wherein the at least one implantable medical device (IMD) is a cardiac pacemaker.

7. The method of claim 5, wherein the at least one implantable medical device (IMD) is an implantable cardioverter defibrillator (ICD).

21. The method of claim 1, further comprising detecting a plurality of outputted modulated signals collected by a plurality of correlated sensors, and providing an indication of at least one cardiac function based on changes in a plurality of complex impedances, the indication providing information regarding a specific region of the heart.

22. The method of claim 1, wherein the cardiac function is cardiac contractility.

8. A system comprising:

at least one electrode configured to propagate a modulated signal across a myocardium;

at least one sensor configured to detect an outputted modulated signal from the myocardium;

at least one circuit configured to reduce the influence of process noise in the outputted modulated signal, wherein the at least one circuit comprises;

an amplifier configured to amplify the outputted modulated signal to produce a second outputted modulated signal;

a demodulator configured to demodulate the second outputted modulated signal to produce a third outputted modulated signal; and

an integrator configured to pass the third outputted modulated signal through to produce a fourth outputted modulated signal; and

at least one processor configured to;

determine an amplitude and phase of the fourth outputted modulated signal, the amplitude and the phase indicating a complex impedance of the myocardium,

monitor the indication of complex impedance for complex impedance patterns of the myocardium, and

based on changes in complex impedance patterns of the myocardium, provide an indication of cardiac function, wherein the cardiac function is at least one of contractility, capture detection, atrium-ventricle optimization, right ventricular function, left ventricular function, cardiac output, or right to left ventricular synchronization.

9. The system of claim 8, wherein the system further comprises a signal generator configured to provide a direct current signal,

wherein the direct current signal is adjustable;

and

a modulator configured to modulate the adjustable direct current signal to produce the modulated signal.

10. The system of claim 9, where the modulated signal has a nominal frequency of approximately 4 kilohertz to prevent interference with functions of other implanted devices.

11. The system of claim 9, wherein the system further comprises:

a signal generator configured to generate a signal when an ischemic event is indicated based on changes in complex impedance patterns of the myocardium, wherein the signal contains an alert message; and

a transmitter configured to insert the signal.

12. The system of claim 9, wherein the system further comprises at least one implantable medical device (IMD).

13. The system of claim 12, wherein the at least one implantable medical device (IMD) is a cardiac pacemaker.

14. The system of claim 12, wherein the at least one implantable medical device (IMD) is an implantable cardioverter defibrillator (ICD).

25. The system of claim 9,

wherein the at least one electrode is a left ventricular tip (LVTIP) electrode, and

wherein the at least one sensor is a right ventricular coil (RVCOIL) sensor.

26. The system of claim 9,

wherein the at least one electrode is a left ventricular tip (LVTIP) electrode, and

wherein the at least one sensor is a right ventricular ring (RVRING) sensor.

27. The system of claim 9,

wherein the at least one electrode is a right ventricular tip (RVTIP) electrode, and

wherein the at least one sensor is a right ventricular ring (RVRING) sensor.

28. The system of claim 9,

wherein the at least one electrode is a left ventricular tip (LVTIP) electrode, and

wherein the at least one sensor is a left superior vena cava coil (SVCCOIL) sensor.

29. The system of claim 9,

wherein the at least one electrode is a right ventricular tip (RVTIP) electrode, and

wherein the at least one sensor is a superior vena cava coil (SVCCOIL) sensor.

15. A system comprising:

at least one electrode means for propagating a modulated signal across a myocardium;

at least one sensor means for detecting an outputted modulated signal from the myocardium;

at least one circuit means for reducing the influence of process noise in the outputted modulated signal, wherein the at least one circuit means comprises;

an amplifier means for amplifying the outputted modulated signal to produce a second outputted modulated signal;

a demodulator means for demodulating the second outputted modulated signal to produce a third outputted modulated signal; and

an integrator means for passing the third outputted modulated signal through to produce a fourth outputted modulated signal; and

at least one processor means for;

determining an amplitude and phase of the fourth outputted modulated signal, the amplitude and phase indicate a complex impedance of the myocardium,

monitoring the indication of complex impedance for complex impedance patterns of the myocardium, and

based on changes in complex impedance patterns of the myocardium, providing an indication of cardiac function and providing an indication of an ischemic event, wherein the cardiac function is at least one of contractility, capture detection, atrium-ventricle optimization, right ventricular function, left ventricular function, cardiac output, or right to left ventricular synchronization.

16. The system of claim 15, wherein the system further comprises means for providing a direct current signal,

wherein the direct current signal is adjustable;

and

means for modulating the adjustable direct current signal to produce the modulated signal.

17. The system of claim 16, wherein the modulated signal has a nominal frequency of approximately 4 kilohertz to prevent interference with functions of other implanted devices.

18. The system of claim 16, wherein the system further comprises:

a signal generator means for generating a signal when the ischemic event is indicated, wherein the signal contains an alert message; and

a transmitter means for transmitting the signal.

19. The system of claim 16, wherein the system further comprises at least one implantable medical device (IMD).

20. The system of claim 19, wherein the at least one implantable medical device (IMD) is a cardiac pacemaker.

23. A method comprising:

propagating a modulated signal across a myocardium;

detecting an outputted modulated signal from the myocardium;

using at least one circuit to reduce the influence of process noise in the outputted modulated signal, wherein the at least one circuit reduces the influence of process noise by at least;

amplifying the outputted modulated signal to produce a second outputted modulated signal;

demodulating the second outputted modulated signal to produce a third outputted modulated signal; and

passing the third outputted modulated signal through an integrator to produce a fourth outputted modulated signal;

determining an amplitude and phase of the fourth outputted modulated signal, the amplitude and the phase indicating a complex impedance of the myocardium;

monitoring the indication of complex impedance for complex impedance patterns of the myocardium; and

based on changes in complex impedance patterns of the myocardium, providing an indication of an ischemic event and, determining an area of the ischemic event based on a location of propagation of the modulated signal across the myocardium.

24. The method of claim 23, further comprising:

determining the location of propagation based on changes in patterns sensed by a combination of correlated sensors for specific regions of the heart, and providing an indication of the area of the ischemic event.