Methods for promoting intrinsic activation in single chamber implantable cardiac pacing systems

• US 8,478,407 B2
• Filed: 07/28/2011
• Issued: 07/02/2013
• Est. Priority Date: 07/28/2011
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Demmer, Wade M., Kleckner, Karen J., Belk, Paul A.
• Primary Examiner(s): Holmes, Rex R
• Application Number:
  US13/192,706
• Publication Number:
  US 20130030483A1
• Time in Patent Office: 705 Days
• Field of Search: 607/9, 607/17, 607/27
• US Class Current: 607/17
• CPC Class Codes: A61N 1/36507 controlled by gradient or slope of the heart potential
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36592 controlled by the heart rate variability

Abstract

Cardiac pacing methods for an implantable single chamber pacing system, establish an offset rate for pacing at a predetermined decrement from either a baseline rate (i.e. dictated by a rate response sensor), or an intrinsic rate. Pacing maintains the offset rate until x of y successive events are paced events, at which time the offset rate is switched to the baseline rate for pacing over a predetermined period of time. Following the period, if an intrinsic event is not immediately detected, within the interval of the offset rate, the rate is switched back to baseline for pacing over an increased period of time. Some methods establish a preference rate, between the offset and baseline rates, wherein an additional criterion, for switching from the offset rate to the baseline rate, is established with respect to the preference rate.

Claims

1. A method for rate adaptive cardiac pacing that employs implanted electrodes for single chamber pacing and sensing and one or more rate response sensors;

and the method comprising the steps of;

establishing a baseline rate for pacing stimulation according to input from the one or more rate response sensors;

establishing an offset rate for pacing stimulation, the offset rate being lower than the baseline rate and generally tracking therewith such that a difference between the baseline rate and the offset rate remains substantially constant over time;

sensing for intrinsic events by means of the implanted electrodes;

applying a pacing stimulation pulse by means of the implanted electrodes, when an intrinsic event is not detected within a time interval necessary to at least maintain the offset rate, the applied pacing stimulation pulse creating a paced event to maintain the offset rate;

switching from the offset rate to the baseline rate and pacing at the baseline rate over a predetermined period of time, when x of y successive events are paced events, x being greater than one and y being greater than or equal to x; and

at the end of the predetermined period of time, again sensing for intrinsic events, and repeating the above last two steps;

wherein the offset rate is established according to a predetermined decrement of one of;

the baseline rate; and

a greater of the baseline rate and an intrinsic rate, the intrinsic rate being determined by the sensing for intrinsic events; and

further comprising;

establishing a preference rate that falls between the baseline rate and the offset rate; and

switching from the offset rate to the baseline rate and pacing at the baseline rate over the predetermined period of time, when the rates of successive intrinsic events, over a predetermined interval, even if greater than the offset rate, meet a criterion with respect to the preference rate, the criterion being one of;

x of y successive intrinsic events falling below the preference rate over the predetermined interval, x being greater than one and y being greater than or equal to x; and

a measure of central tendency of the rates of successive intrinsic events falling below the preference rate over the predetermined interval.

2. The method of claim 1, wherein the predetermined period of time is shortened in response to detection of intrinsic events occurring at a rate that is greater than the baseline rate.

3. The method of claim 1, wherein the preference rate is established according to a predetermined decrement of the baseline rate, the predetermined decrement being one or a combination of:

a fixed beats per minute decrement, a percentage beats per minute decrement, a fixed interval increment, and a percentage interval increment.

4. The method of claim 1, further comprising applying at least one pacing stimulation pulse at a rate between the preference rate and the baseline rate, when the rates of successive intrinsic events meet the criterion with respect to the preference rate, and just prior to the corresponding switch to the baseline rate.

5. The method of claim 1, wherein, at the end of the predetermined period of time, if an intrinsic event is not immediately detected within the time interval necessary to at least maintain the offset rate, switching back to the baseline rate and pacing at the baseline rate over a another predetermined period of time that is increased from the previous predetermined period.

6. The method of claim 1, wherein, at the end of the predetermined period of time, if an intrinsic event is not immediately detected within the time interval necessary to at least maintain the offset rate, switching back to the baseline rate and pacing at the baseline rate over a another predetermined period of time that is increased from the previous predetermined period.

7. The method of claim 1, wherein the offset rate is established according to a predetermined decrement of the baseline rate, the predetermined decrement being one or a combination of:

a fixed beats per minute decrement, a percentage beats per minute decrement, a fixed interval increment, and a percentage interval increment.

8. The method of claim 1, further comprising applying at least one pacing stimulation pulse at a rate between the offset rate and the baseline rate, just prior to the switch to the baseline rate.

9. The method of claim 1, wherein x equals two and y equals three or x and y both equal eight.

10. The method of claim 1, wherein the predetermined period of time is equal to approximately one minute.

11. A single chamber cardiac pacing system configured to be wholly implanted against an endocardial or epicardial surface, the system including a pulse generator having one or more rate response sensors and a microprocessor element being preprogrammed to direct the pulse generator to execute a method comprising the following steps:

establishing a baseline rate for pacing stimulation according to input from the one or more rate response sensors;

establishing an offset rate for pacing stimulation, the offset rate being lower than the baseline rate and generally tracking therewith such that a difference between the baseline rate and the offset rate remains substantially constant over time;

sensing for intrinsic events by means of the implanted electrodes;

applying a pacing stimulation pulse by means of the implanted electrodes, if an intrinsic event is not detected within a time interval necessary to at least maintain the offset rate, the applied pacing stimulation pulse creating a paced event to maintain the offset rate;

switching from the offset rate to the baseline rate and pacing at the baseline rate over a predetermined period of time, if x of y successive events are paced events, x being greater than one and y being greater than or equal to x; and

at the end of the predetermined period of time, again sensing for intrinsic events, and repeating the above last two steps;

wherein the offset rate is established according to a predetermined decrement of one of;

the baseline rate; and

a greater of the baseline rate and an intrinsic rate, the intrinsic rate determined according to prior sensed intrinsic events; and

wherein the method further comprises;

establishing a preference rate that falls between the baseline rate and the offset rate; and

switching from the offset rate to the baseline rate and pacing at the baseline rate over the predetermined period of time, if the rates of successive intrinsic events, over a predetermined interval, even if greater than the offset rate, meet a criterion with respect to the preference rate, the criterion being one of;

x of y successive intrinsic events falling below the preference rate over the predetermined interval, x being greater than one and y being greater than or equal to x; and

a measure of central tendency of the rates of successive intrinsic events falling below the preference rate over the predetermined interval.

12. The system of claim 11, wherein the predetermined period of time is shortened in response to detection of intrinsic events occurring at a rate that is greater than the baseline rate.

13. The system of claim 11, wherein the preference rate is established according to a predetermined decrement of the baseline rate, the predetermined decrement being one or a combination of:

a fixed beats per minute decrement, a percentage beats per minute decrement, a fixed interval increment, and a percentage interval increment.

14. The system of claim 11, wherein the method further comprises applying at least one pacing stimulation pulse at a rate between the preference rate and the baseline rate, when the rates of successive intrinsic events meet the criterion with respect to the preference rate, and just prior to the corresponding switch to the baseline rate.

15. The system of claim 11, wherein, at the end of the predetermined period of time, if an intrinsic event is not immediately detected within the time interval necessary to at least maintain the offset rate, switching back to the baseline rate and pacing at the baseline rate over a another predetermined period of time that is increased from the previous predetermined period.

16. The system of claim 11, wherein the offset rate is established according to a predetermined decrement of the baseline rate, the predetermined decrement being one or a combination of:

a fixed beats per minute decrement, a percentage beats per minute decrement, a fixed interval increment, and a percentage interval increment.

17. The system of claim 11, wherein the method further comprises applying at least one pacing stimulation pulse at a rate between the offset rate and the baseline rate, just prior to the switch to the baseline rate.

18. The system of claim 11, wherein x equals two and y equals three or x and y both equal eight.

19. The system of claim 11, wherein the predetermined period of time is equal to approximately one minute.

20. A method for rate adaptive cardiac pacing that employs implanted electrodes for single chamber pacing and sensing and one or more rate response sensors;

and the method comprising the steps of;

establishing a baseline rate for pacing stimulation according to input from the one or more rate response sensors;

establishing an offset rate for pacing stimulation, the offset rate being lower than the baseline rate;

sensing for intrinsic events by means of the implanted electrodes;

applying a pacing stimulation pulse by means of the implanted electrodes, when an intrinsic event is not detected within a time interval necessary to at least maintain the offset rate, the applied pacing stimulation pulse creating a paced event to maintain the offset rate;

establishing a preference rate that falls between the baseline rate and the offset rate; and

switching from the offset rate to the baseline rate and pacing at the baseline rate over the predetermined period of time, when the rates of successive intrinsic events, over a predetermined interval, even if greater than the offset rate, meet a criterion with respect to the preference rate, the criterion being one of;

x of y successive intrinsic events falling below the preference rate over the predetermined interval;

x being greater than one and y being greater than or equal to x; and

a measure of central tendency of the rates of successive intrinsic events falling below the preference rate over the predetermined interval.

21. A single chamber cardiac pacing system configured to be wholly implanted against an endocardial or epicardial surface, the system including a pulse generator having one or more rate response sensors and a microprocessor element being preprogrammed to direct the pulse generator to execute a method comprising the following steps:

establishing a baseline rate for pacing stimulation according to input from the one or more rate response sensors;

establishing an offset rate for pacing stimulation, the offset rate being lower than the baseline rate;

sensing for intrinsic events by means of the implanted electrodes;

applying a pacing stimulation pulse by means of the implanted electrodes, if an intrinsic event is not detected within a time interval necessary to at least maintain the offset rate, the applied pacing stimulation pulse creating a paced event to maintain the offset rate;

establishing a preference rate that falls between the baseline rate and the offset rate; and

switching from the offset rate to the baseline rate and pacing at the baseline rate over the predetermined period of time, if the rates of successive intrinsic events, over a predetermined interval, even if greater than the offset rate, meet a criterion with respect to the preference rate, the criterion being one of;

x of y successive intrinsic events falling below the preference rate over the predetermined interval, x being greater than one and y being greater than or equal to x; and

a measure of central tendency of the rates of successive intrinsic events falling below the preference rate over the predetermined interval.