Method for determining the concentration of blood glucose

• US 8,478,536 B2
• Filed: 04/03/2007
• Issued: 07/02/2013
• Est. Priority Date: 12/31/2002
• Status: Active Grant

• Current Assignee: Intellectual Ventures I LLC (Intellectual Ventures LLC)
• Original Assignee: Transpacific Systems LLC (Intellectual Ventures LLC)
• Inventors: Wang, Kuo-Jeng, Chen, Jian-Tsz
• Primary Examiner(s): Riggs, II, Larry D
• Application Number:
  US11/695,967
• Publication Number:
  US 20070225583A1
• Time in Patent Office: 2,282 Days
• Field of Search: None
• US Class Current: 702/19
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: C12Q 1/54 involving glucose or galactose

Abstract

The present invention provides a method for determining concentration of blood glucose by using the change in the rising time. The chemical reaction between the blood glucose and enzyme within the test strip to generate the analog source that used to determine the concentration of the blood glucose in the measuring meter. Thus, the rising curve can be obtained after the analog source is treated, such that the concentration of the blood glucose can be determined.

Claims

1. A measuring circuit, comprising:

an amplifier configured to receive an analog signal generated by detection of a product of an oxidation-reduction reaction associated with a concentration of blood glucose on a test strip;

an analog-to-digital conversion device configured to convert the analog signal into a digital signal; and

a processing device configured to execute instructions that cause the processing device to perform operations comprising;

converting the digital signal into a wave pattern;

identifying a first time and a second time based, at least in part, on the wave pattern, wherein the first time is a turning point of the wave pattern and the second time is a peak value of the wave pattern;

calculating a time difference value between the first time and the second time, wherein the time difference value corresponds with a rising time; and

determining the concentration of blood glucose according to the rising time.

2. The measuring circuit of claim 1, wherein:

the analog signal is generated by detection of the product of a chemical reaction between an enzyme and the concentration of blood glucose;

the rising time is a reaction time between the enzyme and the concentration of blood glucose; and

the processing device is further configured to execute the instructions to cause the processing device to perform operations further comprising generating a larger measured value for the concentration of blood glucose when the reaction time is longer and generate a smaller measured value for the concentration of blood glucose when the reaction time is shorter.

19. The measuring circuit of claim 1, wherein the test strip comprises an enzyme.

3. An apparatus, comprising:

a conversion device configured to generate an electrical signal corresponding to a product of an oxidation-reduction reaction associated with a concentration of blood glucose on a test strip; and

a processing device configured to execute instructions that cause the processing device to perform operations comprising;

converting the electrical signal into a wave pattern;

calculating a rise time associated with the wave pattern, wherein the rise time corresponds to a difference between an initial time and a second time, and wherein the second time corresponds approximately to a peak value of the electrical signal; and

correlating a concentration of blood glucose with the rise time.

4. The apparatus of claim 3, wherein the processing device comprises a microprocessor-controlling unit.

5. The apparatus of claim 3, wherein the test strip comprises an enzyme.

6. The apparatus of claim 3, further comprising a display configured to display the concentration of blood glucose.

7. The apparatus of claim 3, wherein the initial time is associated with an initial turning point of the electrical signal.

8. The apparatus of claim 3, wherein the conversion device comprises an amplifier configured to amplify the electrical signal.

9. The apparatus of claim 3, wherein the processing device is further configured to execute the instructions to cause the processing device to perform operations further comprising calculating the rise time, at least in part, according to the wave pattern.

10. An apparatus, comprising:

a detection device configured to generate a signal corresponding to a product of an oxidation-reduction reaction associated with a concentration of blood glucose on a test strip; and

a processing device configured to execute instructions that cause the processing device to perform operations comprising;

converting the signal into a wave pattern;

calculating a rise time associated, at least in part, with the wave pattern, wherein the rise time corresponds to a difference between a first time associated with a turning point of the wave pattern and a second time associated with a peak value of the wave pattern; and

determining the concentration of blood glucose according to the rise time.

11. A method, comprising:

generating a signal corresponding to detection of a product an oxidation-reduction reaction associated with a concentration of blood glucose on a test strip;

calculating a rise time of the signal with a treatment device, wherein the rise time corresponds to a difference between an initial time of the signal and a peak time corresponding approximately to a largest value of the signal; and

correlating with the treatment device a concentration of blood glucose according to the rise time.

12. The method of claim 11, further comprising:

generating a wave pattern from the signal that identifies the initial time and the peak time; and

correlating the concentration of blood glucose according to the wave pattern.

13. The method of claim 11, further comprising calculating a first order differential from the signal to identify the largest value of the signal.

14. The method of claim 11, further comprising using a look-up table to correlate the concentration of blood glucose.

15. The method of claim 11, wherein the initial time is associated with a turning point of the signal.

16. A method, comprising:

generating an electrical signal with an input device, wherein the electrical signal corresponds to a product of an oxidation-reduction reaction associated with blood glucose on a test strip;

generating a wave pattern according to the electrical signal;

identifying a first time associated with a turning value in the wave pattern;

identifying a second time associated with a second substantially plateaued value in the wave pattern; and

calculating a blood glucose level according to a difference between the first time and the second time.

17. The method of claim 16, wherein the second substantially plateaued value is substantially a peak value of the wave pattern.

18. The method of claim 16, further comprising using a look-up table to map the difference between the first time and the second time to the blood glucose level.