System for detecting, diagnosing, and treating cardiovascular disease

• US 8,480,594 B2
• Filed: 10/03/2006
• Issued: 07/09/2013
• Est. Priority Date: 01/11/2000
• Status: Active Grant

• Current Assignee: Cedars-Sinai Medical Center (Cedars Sinai Health System)
• Original Assignee: Cedars-Sinai Medical Center (Cedars Sinai Health System)
• Inventors: Eigler, Neal L., Whiting, James S.
• Primary Examiner(s): Natnithithadha, Navin
• Application Number:
  US11/542,386
• Publication Number:
  US 20070032831A1
• Time in Patent Office: 2,471 Days
• Field of Search: 600/481, 600483-486, 600/488, 600/508
• US Class Current: 600/486
• CPC Class Codes: A61B 2560/0209 adapted for power saving
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6882 Anchoring means
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

The invention provides improved apparatus and methods for treating congestive heart failure in a medical patient. The apparatus includes a pressure transducer permanently implantable within the left atrium of the patient'"'"'s heart and operable to generate electrical signals indicative of fluid pressures within the patient'"'"'s left atrium. The pressure transducer is connected to a flexible electrical lead, which is connected in turn to electrical circuitry, which in the preferred embodiment includes digital circuitry for processing electrical signals. The electrical circuitry processes the electrical signals from the pressure transducer and, based at least in part on those signals, generates a signal that indicates a desired therapeutic treatment for treating the patient'"'"'s condition. That signal is then communicated to the patient via a patient signaling device, following which the patient administers to him or herself the prescribed therapeutic treatment indicated by the signal.

Claims

1. A system for treating congestive heart failure in a medical patient, the system comprising:

a first sensor, wherein said first sensor comprises a pressure transducer that generates a signal indicative of fluid pressure within a heart;

a signal processing apparatus that generates an instructive signal that instructs the patient to take an appropriate therapeutic treatment to control the pressure within the patient'"'"'s heart, based at least in part on the signal generated by the pressure transducer;

a patient signaling device that communicates the instructive signal indicative of the appropriate therapeutic treatment to the patient, wherein the patient signaling device generates at least two distinct signals distinguishable from one another by the patient, each said signal indicative of a different therapeutic treatment; and

a housing, wherein at least a portion of a device selected from the group consisting of one or more of the following;

said signal processing apparatus, said pressure transducer, and said patient signaling device, is contained within or disposed on said housing.

2. The system of claim 1, wherein said housing and said pressure transducer are an integrated unit.

3. The system of claim 1, further comprising a flexible lead, wherein said lead provides a signal connection between the pressure transducer and the housing.

4. The system of claim 3, wherein said lead comprises at least one of a cardiac pacing lead or a defibrillator lead.

5. The system of claim 4, wherein said lead comprises a sensor lead combined with at least one of said cardiac pacing lead or said defibrillator lead.

6. The system of claim 3, wherein said lead comprises a plurality of leads.

7. The system of claim 3, further comprising an additional lead, wherein said additional lead is coupled to apparatus that anchors the pressure transducer to the patient'"'"'s atrial septum.

8. The system of claim 1, further comprising apparatus that anchors the pressure transducer to the patient'"'"'s atrial septum.

9. The system of claim 1, wherein the signal processing apparatus comprises an analog-to-digital converter that converts analog signals from the pressure transducer to digital data reflective of the fluid pressure within the heart.

10. The system of claim 1, wherein the signal processing apparatus comprises digital memory for storing data reflective of pressures within the heart.

11. The system of claim 1, wherein the patient signaling device provides written, visual, or spoken instructions to the patient.

12. The system of claim 11, wherein said instructions are provided on a hand-held device.

13. The system of claim 11, wherein said instructions comprise therapeutic instructions.

14. The system of claim 1, wherein at least one of said two distinct signals is communicated to the patient at least once during a predetermined monitoring period.

15. The system of claim 1, wherein at least one of said two distinct signals comprises information that the patient should not change therapy.

16. The system of claim 1, wherein at least one of said two distinct signals comprises information that the patient should reduce therapy.

17. The system of claim 1, further comprising a second sensor, wherein the second sensor generates a second signal indicative of a second condition within the body of the patient, wherein the signal processing apparatus generates a signal indicative of an appropriate therapeutic treatment based at least in part on the second signal generated by the second sensor.

18. The system of claim 17, wherein the second sensor is a second pressure transducer or an ECG electrode.

19. A system for treating congestive heart failure in a medical patient, the system comprising:

means for generating a signal indicative of fluid pressure within a patient'"'"'s heart;

means for generating an instructive signal;

wherein said instructive signal instructs the patient to take an appropriate therapeutic treatment to control the pressure within the patient'"'"'s heart, based at least in part on signals generated by the means for generating a signal indicative of fluid pressure;

means for communicating the instructive signal indicative of the appropriate therapeutic treatment to the patient, and

wherein the means for communicating the instructive signal generates at least a first signal and a second signal,

wherein said first and second signals are distinguishable from one another by the patient,

wherein said first signal indicates a first therapeutic treatment, wherein said second signal indicates a second therapeutic treatment, and wherein said first signal is different from said second signal.

20. The system of claim 19, wherein said means for generating a signal indicative of fluid pressure comprises a pressure transducer.

21. The system of claim 19, wherein said means for generating an instructive signal comprises a signal processor.

22. The system of claim 19, wherein said means for communicating the instructive signal comprises a patient signaling device.