Method for increased uptake of beneficial agent and ejection fraction by postconditioning procedures

• US 8,480,650 B2
• Filed: 04/29/2011
• Issued: 07/09/2013
• Est. Priority Date: 04/30/2010
• Status: Active Grant

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Magana, Jesus, Consigny, Paul, Hossainy, Syed, Ehrenreich, Kevin
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): Snyder, Melissa A
• Application Number:
  US13/098,092
• Publication Number:
  US 20110270225A1
• Time in Patent Office: 802 Days
• Field of Search: 604/99.02, 604/99.01, 604/96.01, 604508-509
• US Class Current: 604/509
• CPC Class Codes: A61M 2025/004 characterized by lumina being arranged circumferentially
• CPC Class Codes: A61M 2025/0081 Soft tip
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1088 having special surface characteristics depending on material properties or added substances, e.g. for reducing friction
• CPC Class Codes: A61M 2039/248 Ball-valve
• CPC Class Codes: A61M 25/0021 characterised by the form of the tubing A61M25/0054 takes precedence
• CPC Class Codes: A61M 25/1002 characterised by balloon shape A61M25/1006, A61M25/1009 take precedence
• CPC Class Codes: A61M 25/10184 Means for controlling or monitoring inflation or deflation
• CPC Class Codes: A61M 25/10185 Valves
• CPC Class Codes: A61M 25/10187 Indicators for the level of inflation or deflation
• CPC Class Codes: A61M 25/104 used for angioplasty

Abstract

A method for improving tissue uptake of beneficial agent and ejection fraction.

Claims

1. A method of improving tissue uptake of a beneficial agent, the method comprising:

introducing a balloon of a balloon catheter into a lumen of a blood vessel of a subject, the balloon being configured to inflate in less than four seconds and deflate in less than five seconds;

inflating the balloon in less than four seconds and maintaining inflation for a period of time;

deflating the balloon in less than five seconds, and

locally administering the beneficial agent into the lumen of the blood vessel,

wherein the beneficial agent is administered while the balloon is inflated.

2. A method of improving tissue uptake of a beneficial agent, the method comprising:

introducing a balloon of a balloon catheter into a lumen of a blood vessel of a subject, the balloon being configured to inflate in less than four seconds and deflate in less than five seconds;

inflating the balloon in less than four seconds and maintaining inflation for a period of time;

deflating the balloon in less than five seconds, and

locally administering the beneficial agent into the lumen of the blood vessel,

wherein the beneficial agent is administered while the balloon is deflated.

3. A method of improving tissue uptake of a beneficial agent, the method comprising:

introducing a balloon of a balloon catheter into a lumen of a blood vessel of a subject, the balloon being configured to inflate in less than four seconds and deflate in less than five seconds;

inflating the balloon in less than four seconds and maintaining inflation for a period of time;

deflating the balloon in less than five seconds, and

locally administering the beneficial agent into the lumen of the blood vessel,

wherein the beneficial agent is administered while the balloon is both inflated and deflated.

4. A method of improving tissue uptake of a beneficial agent, the method comprising:

introducing a balloon of a balloon catheter into a lumen of a blood vessel of a subject, the balloon being configured to inflate in less than four seconds and deflate in less than five seconds;

inflating the balloon in less than four seconds and maintaining inflation for a period of time;

deflating the balloon in less than five seconds, and

locally administering the beneficial agent into the lumen of the blood vessel,

wherein the improved uptake of beneficial agent exhibits a concentration of beneficial agent in blood plasma at least one hour after cessation of administration.

5. The method of claim 4, wherein the method exhibits a plasma concentration of beneficial agent at least two hours after cessation of administration of the beneficial agent and inflation and deflation of the balloon.

6. A method of improving tissue uptake of a beneficial agent, the method comprising:

introducing a balloon of a balloon catheter into a lumen of a blood vessel of a subject, the balloon being configured to inflate in less than four seconds and deflate in less than five seconds;

inflating the balloon in less than four seconds and maintaining inflation for a period of time;

deflating the balloon in less than five seconds, and

locally administering the beneficial agent into the lumen of the blood vessel,

wherein the beneficial agent is selected from the group consisting of;

a calpain inhibitor, pH stabilizing agent, and an endothelin receptor blocker.

7. A method of improving tissue uptake of a beneficial agent, the method comprising:

introducing a balloon of a balloon catheter into a lumen of a blood vessel of a subject, the balloon being configured to inflate in less than four seconds and deflate in less than five seconds;

inflating the balloon in less than four seconds and maintaining inflation for a period of time;

deflating the balloon in less than five seconds, and

locally administering the beneficial agent into the lumen of the blood vessel,

wherein the beneficial agent includes a biomaterial.

8. A method of improving the ejection fraction after an ischemic event in a subject, comprising:

introducing into an ischemic lumen of the subject a catheter having an inflation lumen and an separate dedicated deflation lumen disposed between a proximal end and a distal end of the catheter and a balloon disposed on the catheter;

sequentially inflating and deflating the balloon for at least two cycles,

wherein the ejection fraction in the subject is at least 30%.

9. The method of claim 8, wherein the ejection fraction is at least 33%.

10. The method of claim 8, wherein the ejection fraction is at least 35%.

11. The method of claim 8, wherein the ejection fraction of 30% is maintained for over 7 days.

12. The method of claim 8, wherein the ejection fraction is maintained for over 28 days.

13. The method of claim 8, wherein the ejection fraction increases over time.

14. The method of claim 13, wherein the ejection fraction increases to 40%.

15. The method of claim 13, wherein the ejection fraction increases to at least 50%.