Thin films for controlled protein interaction
First Claim
1. A medium for isolating or releasing an electrostatically charged component from or into an aqueous composition, the medium comprising a polyelectrolyte film on at least one surface of an article:
- the polyelectrolyte film comprises an interpenetrating network of a predominantly positively charged polymer and a predominantly negatively charged polymer;
the predominantly positively charged polymer, the predominantly negatively charged polymer or both contain (i) a copolymer comprising a pH sensitive imidazole repeat unit having a pKa between 3 and 9 and a charged pH insensitive repeat unit, or (ii) a redox sensitive repeat unit selected from the group consisting of quaternized bipyridine repeat units, coordinated metal repeat units, pyrrole repeat units, aniline repeat units, thiophene repeat units and combinations thereof having a redox potential between +1.2 volts and −
1.2 volts versus a standard hydrogen electrode; and
the article is (iii) a porous substrate when the predominantly positively charged polymer, the predominantly negatively charged polymer or both contain the pH sensitive imidazole repeat unit or (iv) an electrically conductive substrate when the predominantly positively charged polymer, the predominantly negatively charged polymer or both contain the redox sensitive repeat unit.
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Abstract
A medium for isolating or releasing an electrostatically charged component from or into an aqueous composition. The medium has a polyelectrolyte film on at least one surface of an article wherein the polyelectrolyte film is characterized by an interpenetrating network of a predominantly positively charged polymer and a predominantly negatively charged polymer. The predominantly positively charged polymer, the predominantly negatively charged polymer or both contain (i) a pH sensitive imidazole repeat unit having a pKa between 3 and 9, or (ii) a redox sensitive repeat unit selected from the group consisting of quaternized bipyridine repeat units, coordinated metal repeat units, pyrrole repeat units, aniline repeat units, thiophene repeat units and combinations thereof having a redox potential between +1.2 volts and −1.2 volts versus a standard hydrogen electrode.
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Citations
23 Claims
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1. A medium for isolating or releasing an electrostatically charged component from or into an aqueous composition, the medium comprising a polyelectrolyte film on at least one surface of an article:
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the polyelectrolyte film comprises an interpenetrating network of a predominantly positively charged polymer and a predominantly negatively charged polymer; the predominantly positively charged polymer, the predominantly negatively charged polymer or both contain (i) a copolymer comprising a pH sensitive imidazole repeat unit having a pKa between 3 and 9 and a charged pH insensitive repeat unit, or (ii) a redox sensitive repeat unit selected from the group consisting of quaternized bipyridine repeat units, coordinated metal repeat units, pyrrole repeat units, aniline repeat units, thiophene repeat units and combinations thereof having a redox potential between +1.2 volts and −
1.2 volts versus a standard hydrogen electrode; andthe article is (iii) a porous substrate when the predominantly positively charged polymer, the predominantly negatively charged polymer or both contain the pH sensitive imidazole repeat unit or (iv) an electrically conductive substrate when the predominantly positively charged polymer, the predominantly negatively charged polymer or both contain the redox sensitive repeat unit. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A medium for isolating or releasing an electrostatically charged component from or into an aqueous composition, the medium comprising a polyelectrolyte film on at least one surface of an article:
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the polyelectrolyte film comprises an interpenetrating network of a predominantly positively charged polymer and a predominantly negatively charged polymer; the predominantly positively charged polymer, the predominantly negatively charged polymer or both contain a pH sensitive imidazole repeat unit having a pKa between 3 and 9 wherein the imidazole repeat unit has the structure;
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Specification