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Tyrosine kinase microspheres

  • US 8,481,069 B2
  • Filed: 04/29/2005
  • Issued: 07/09/2013
  • Est. Priority Date: 04/30/2004
  • Status: Active Grant
First Claim
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1. A biodegradable intravitreal implant comprising:

  • a plurality of biodegradable polymer microspheres comprising a tyrosine kinase inhibitor (TKI) and a biodegradable polymer matrix, the microspheres releasing the TKI at a rate effective to sustain release of the TKI from the microspheres for at least about one week to about 1 year after the implant is placed in the vitreous of an eye, wherein the tyrosine kinase inhibitor is provided in an amount from about 40% by weight to about 60% by weight of the implant, and the biodegradable polymer matrix comprises a poly(lactide-co-glycolide) in an amount from about 40% by weight to about 60% by weight of the implant.

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