Hydrogel compositions with an erodible backing member

• US 8,481,071 B2
• Filed: 05/29/2012
• Issued: 07/09/2013
• Est. Priority Date: 05/01/2001
• Status: Expired due to Term

• Current Assignee: A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences,, Corium LLC
• Original Assignee: Corium International, Inc.
• Inventors: Singh, Parminder, Cleary, Gary W., Mudumba, Sri, Feldstein, Mikhail M., Bairamov, Danir F., Faasse, Adrian
• Primary Examiner(s): GHALI, ISIS A D
• Application Number:
  US13/482,965
• Publication Number:
  US 20120237579A1
• Time in Patent Office: 406 Days
• Field of Search: None
• US Class Current: 424/434
• CPC Class Codes: A61C 19/066 Bleaching devices; Whitening agent applicators for teeth, e.g. trays or strips
• CPC Class Codes: A61K 2800/262 Transparent; Translucent
• CPC Class Codes: A61K 2800/54 Polymers characterized by specific structures/properties
• CPC Class Codes: A61K 2800/5422 nonionic
• CPC Class Codes: A61K 8/0204 Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/22 Peroxides; Oxygen; Ozone
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 8/733 Alginic acid; Salts thereof
• CPC Class Codes: A61K 8/8147 Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/8152 Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/817 Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
• CPC Class Codes: A61K 8/8176 Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61L 15/60 Liquid-swellable gel-forming materials, e.g. super-absorbents
• CPC Class Codes: A61L 15/64 specially adapted to be resorbable inside the body
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: C08L 2312/00 Crosslinking

Abstract

A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer. The composition also includes a backing member. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening. The composition can be designed to be removed when the degree of whitening has been achieved or left in place and allowed to erode entirely. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.

Claims

1. A composition, comprising:

(a) a hydrogel comprising;

(i) a water-swellable, water-insoluble acrylate polymer;

(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and

(iii) an active agent; and

(b) a backing member comprising a cellulose polymer, wherein the backing member erodes in a moist environment at a slower rate than the hydrogel.

2. The composition of claim 1, wherein the acrylate polymer is selected from polymers and copolymers of acrylic acid, methacrylic acid, methyl acrylate, ethyl acrylate, methyl methacrylate, or ethyl methacrylate.

3. The composition of claim 1, wherein the acrylate polymer is a methacrylic acid-methyl methacrylate copolymer.

4. The composition of claim 1, wherein the acrylate polymer is a methacrylic acid-ethyl acrylate copolymer.

5. The composition of claim 2, comprising between about 1-20 wt % of acrylate polymer.

6. The composition of claim 3, comprising between about 1-20 wt % of acrylate polymer.

7. The composition of claim 4, comprising between about 1-20 wt % of acrylate polymer.

8. The composition of claim 1, wherein the hydrophilic polymer is a poly(N-vinyl-lactams).

9. The composition of claim 8, which comprises about 20-80 wt % of a hydrophilic polymer.

10. The composition of claim 1, wherein the complementary oligomer is a polyalkylene glycols.

11. The composition of claim 10, which comprises about 10-50 wt % of a complementary oligomer.

12. The composition of claim 1, the cellulose polymer is selected from methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, and mixtures thereof.

13. The composition of claim 1, wherein the cellulose polymer is a cellulose ester.

14. The composition of claim 1, wherein the hydrogel erodes about 1 second to 24 hours after placement in a moist environment.

15. The composition of claim 1, wherein the hydrogel erodes about 10 seconds to 8 hours after placement in a moist environment.

16. The composition of claim 1, wherein the backing member erodes at least about 25% slower than the hydrogel.

17. The composition of claim 1, wherein the backing member erodes at least about 50% slower than the hydrogel.

18. The composition of claim 1, wherein the hydrogel is a solid and is attached to the backing member prior to use.

19. The composition of claim 1, wherein the active agent is a whitening agent selected from the group consisting of peroxides, metal chlorites, perborates, percarbonates, peroxyacids, and combinations thereof.

20. The composition of claim 1, wherein the active agent is selected from the group consisting of hydrogen peroxide, calcium peroxide, magnesium peroxide, carbamide peroxide, and mixtures thereof.

21. A method for whitening teeth, comprising:

applying to teeth a composition comprising;

(a) a hydrogel comprising;

(i) a water-swellable, water-insoluble acrylate polymer;

(ii) a blend of a hydrophilic polymer with a complementary oligomer capable of hydrogen or electrostatic bonding to the hydrophilic polymer; and

(iii) an active agent; and

(b) a backing member comprising a cellulose polymer, wherein the backing member erodes in a moist environment at a slower rate than the hydrogel.

22. The method of claim 21, wherein the hydrogel is a solid and is attached to the backing member, and wherein the applying step comprises applying the composition in a single step.

23. The method of claim 21 wherein the composition includes a release liner, and the release liner is removed prior to application of the composition to the teeth.