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Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use

  • US 8,481,073 B2
  • Filed: 10/24/2011
  • Issued: 07/09/2013
  • Est. Priority Date: 04/28/2004
  • Status: Active Grant
First Claim
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1. A method of preventing adhesions between tissues of a patient, comprising:

  • (a) providing a dry powder composition including;

    i. a first component having a first hydrophilic polymer core substituted with m thiol groups, where m≧

    2; and

    ii. a second component having a second hydrophilic polymer core substituted with n electrophilic groups, where n≧

    2 and m+n>

    4, and wherein the electrophilic group is independently —

    (CO)—

    O—

    (CO)—

    R (where R is an alkyl group), CH═

    CH—

    CH═

    O, —

    CH═

    CH—

    C(CH3)═

    O, —

    N═

    C═

    O, —

    N═

    C═

    S, —

    SO2CH═

    CH2, —

    O(CO)—

    C═

    CH2, —

    (CO)—

    C(CH3)═

    CH2, —

    S—

    S—

    (C5H4N), —

    O(CO)—

    C(CH2CH3)═

    CH2, —

    CH═

    CH—

    C═

    NH, —

    COOH, —

    (CO)O—

    N(COCH2)2, —

    O—

    (CO)—

    O—

    N(COCH2)2, —

    CHO, —

    (CO)O—

    N(COCH2)2

    S(O)2OH, and —

    N(COCH)2;

    (b) rendering the nucleophilic and electrophilic groups reactive by exposing the composition to an aqueous environment to effect inter-reaction;

    wherein said exposure comprises;

    (i) dissolving the dry powder composition in a first solution having a pH within the range of about 2.1-2.3 to form a homogeneous solution, and(ii) adding a second solution having a pH within the range of about 6.0 to 11.0 to the homogeneous solution to form a mixture; and

    (c) placing the mixture into contact with tissue and allowing a three-dimensional composition to form on the tissue.

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