Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
First Claim
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1. A method of preventing adhesions between tissues of a patient, comprising:
- (a) providing a dry powder composition including;
i. a first component having a first hydrophilic polymer core substituted with m thiol groups, where m≧
2; and
ii. a second component having a second hydrophilic polymer core substituted with n electrophilic groups, where n≧
2 and m+n>
4, and wherein the electrophilic group is independently —
(CO)—
O—
(CO)—
R (where R is an alkyl group), CH═
CH—
CH═
O, —
CH═
CH—
C(CH3)═
O, —
N═
C═
O, —
N═
C═
S, —
SO2CH═
CH2, —
O(CO)—
C═
CH2, —
(CO)—
C(CH3)═
CH2, —
S—
S—
(C5H4N), —
O(CO)—
C(CH2CH3)═
CH2, —
CH═
CH—
C═
NH, —
COOH, —
(CO)O—
N(COCH2)2, —
O—
(CO)—
O—
N(COCH2)2, —
CHO, —
(CO)O—
N(COCH2)2—
S(O)2OH, and —
N(COCH)2;
(b) rendering the nucleophilic and electrophilic groups reactive by exposing the composition to an aqueous environment to effect inter-reaction;
wherein said exposure comprises;
(i) dissolving the dry powder composition in a first solution having a pH within the range of about 2.1-2.3 to form a homogeneous solution, and(ii) adding a second solution having a pH within the range of about 6.0 to 11.0 to the homogeneous solution to form a mixture; and
(c) placing the mixture into contact with tissue and allowing a three-dimensional composition to form on the tissue.
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Abstract
Methods of preventing adhesion between issues are provided that utilizes in situ crosslinked biomaterials. The biomaterial contains at least the crosslinked product of two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Exemplary uses for the crosslinked compositions include preventing adhesions following surgery or injury, and preventing scar tissue formation.
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Citations
10 Claims
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1. A method of preventing adhesions between tissues of a patient, comprising:
-
(a) providing a dry powder composition including; i. a first component having a first hydrophilic polymer core substituted with m thiol groups, where m≧
2; andii. a second component having a second hydrophilic polymer core substituted with n electrophilic groups, where n≧
2 and m+n>
4, and wherein the electrophilic group is independently —
(CO)—
O—
(CO)—
R (where R is an alkyl group), CH═
CH—
CH═
O, —
CH═
CH—
C(CH3)═
O, —
N═
C═
O, —
N═
C═
S, —
SO2CH═
CH2, —
O(CO)—
C═
CH2, —
(CO)—
C(CH3)═
CH2, —
S—
S—
(C5H4N), —
O(CO)—
C(CH2CH3)═
CH2, —
CH═
CH—
C═
NH, —
COOH, —
(CO)O—
N(COCH2)2, —
O—
(CO)—
O—
N(COCH2)2, —
CHO, —
(CO)O—
N(COCH2)2—
S(O)2OH, and —
N(COCH)2;(b) rendering the nucleophilic and electrophilic groups reactive by exposing the composition to an aqueous environment to effect inter-reaction;
wherein said exposure comprises;(i) dissolving the dry powder composition in a first solution having a pH within the range of about 2.1-2.3 to form a homogeneous solution, and (ii) adding a second solution having a pH within the range of about 6.0 to 11.0 to the homogeneous solution to form a mixture; and (c) placing the mixture into contact with tissue and allowing a three-dimensional composition to form on the tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification